Factors such as oxidative stress and reduced acetylcholine level have been implicated in Alzheimer’s disease (AD) pathology and recently there has been a trend towards natural product research to find potential sources of antioxidants and acetylcholinesterase inhibitors in the plants kingdom. Centaurea is a genus with about 500 species world wild, many of them have shown to possess bio...

objective(s): alzheimer's disease (ad) is a neurodegenerative disorder in elderly patients. decrease in cholinergic neurotransmission is the main known cause in the pathophysiology of the disease. improvement and potentiation of the cholinergic system could be beneficial for treatment of the ad. acetylcholinesterase inhibitors such as donepezil can enhance the duration of action of acetylc...

Objective: Brain acetylcholinesterase activity was determined in healthy controls and in patients with mild cognitive impairment and early Alzheimer’s disease. Methods: A specific acetylcholinesterase tracer, [methylC]N-methyl-piperidyl-4-acetate ([C]MP4A), and a three dimensional PET system with magnetic resonance coregistration were used for imaging. Results: There was a significant differenc...

The effect of Annona squamosa, Lawsonia inermis and their combination with other herbal molluscicides were studied on different enzyme activity in the nervous tissue of Lymnaea acuminata. Twenty-Four hour in vivo exposure to 40% and 80% of 24 h LC50 of plant derived molluscicides and their combination with other molluscicides such as Cedrus deodara, Azadirachta indica oil, Allium sativum, Polia...

BACKGROUND & AIMS There have been many studies on plasma butyrylcholinesterase in liver dysfunction. However, no data is available about acetylcholinesterase in human cirrhosis, although profound changes have been described in cirrhotic rat models. METHODS Human serum and liver acetylcholinesterase and its molecular forms were determined enzymatically, after butyrylcholinesterase immunodeplet...

Alzheimer's Disease (AD) is one of the consequences impaired functioning acetylcholine which can be hydrolyzed by enzyme acetylcholinesterase. treatment carried out using two approaches, namely compounds (acetylcholinesterase inhibitors) and noncholinergics (antioxidants). There are commercial drugs that slow progression Alzheimer's, but their use cause excessive side effects. The herbal plants...

Objective(s): Alzheimer’s disease (AD) as progressive cognitive decline and the most common form of dementia is due to degeneration of the cholinergic neurons in the brain. Therefore, administration of the acetylcholinesterase (AChE) inhibitors such as donepezil is the first choice for treatment of the AD. In the present study, we focused on the synthesis and anti-cholinesterase evaluation of n...

the effects of cadmium and lead on human erythrocyte acetylcholinesterase activity were studied. blood used in this study was obtained from 24 healthy individuals, then after hemolysation, treated with 3 various concentrations of cadmium and lead. a strong inhibition of acetylcholinesterase was noted in treated samples by cadmium and lead. the remaining activity in the case of lead, the remaini...

In the present study, the effect of acute and chronic immobilization stress on brain acetylcholinesterase (AChE) enzyme activity and cognitive function in mice was investigated. Mice were immobilized by strapping for 150 min. One group of mice were only immobilized once (acute stress) while in another group mice were immobilized (150 min) daily for 5 consecutive days (chronic stress). Specific ...