We previously reported that acetylcholinesterase plays a critical role in apoptosis and its expression is regulated by Ca(2+) mobilization. In the present study, we show that activated calpain, a cytosolic calcium-activated cysteine protease, and calcineurin, a calcium-dependent protein phosphatase, regulate acetylcholinesterase expression during A23187-induced apoptosis. The calpain inhibitor,...

background: galantamine is a drug used for the treatment of alzheimer’s disease and some other cognitive disorders. it is an inhibitor of acetylcholinesterase however, interaction with nicotinic acetylcholine receptors has also been reported. owing to the significant role of cholinergic anti-inflammatory pathways in neuro-immunomodulation, we decided to examine the effect of galantamine on tula...

The distribution of acetylcholinesterase in the canine kidney was studied by the histochemical method of Karnovsky and Roots and compared to the distribution of adrenergic fibers studied with the fluorescence histochemical method of Falck and Hillarp. Specific inhibitors of nonspecific cholinesterase and acetylcholinesterase were used to differentiate between the two enzymes. In the hilus, acet...

the toxicity of chlorpyrifos to three iranian populations of two-spotted spider mite, collected from isfahan (isr), yazd (yz) and guilan (gus2) provinces were surveyed using the residual contact vial bioassay. the bioassay results showed that resistance ratios of isr and yz populations were 176.90 and 9.78 fold compared to the gus2 population, respectively. determination of esterase and glutath...

Acetylcholinesterase purified from cobra (Naja naja) venom exhibits a serotonin-sensitive aryl acylamidase activity. Both acetylcholinesterase and aryl acylamidase activities co-eluted in column chromatographic procedures (Sephadex G-75 and Zinc-Sepharose), co-migrated on polyacrylamide gel electrophoresis, co-immunoprecipitated by anti-snake venom antibody and showed the same heat denaturation...

Alzheimer's Disease (AD) is one of the consequences impaired functioning acetylcholine which can be hydrolyzed by enzyme acetylcholinesterase. treatment carried out using two approaches, namely compounds (acetylcholinesterase inhibitors) and noncholinergics (antioxidants). There are commercial drugs that slow progression Alzheimer's, but their use cause excessive side effects. The herbal plants...

the effects of zinc and mercury on human erythrocyte acetylcholinestrase activity were studied. blood used in this study was obtained from 24 apparently healthy individuals and after hemolysation, was treted with 3 diferent concentrations of zinc and mercury. significant suppressions in acetylcholinestrase activity were recorded in treated samples by zinc and mercury. when compared to controls ...

in this work, the effect of ligand's length on interaction energy of six oximes, a [2-(hydroxyimino)-n-((1-(2-(2-((hydroxyimino)methyl)-1h-imidazol-1-yl)ethyl)-1h-1,2,3-triazol-4-yl)methyl)acetamide], b [2-(hydroxyimino)-n-((1-(3-(2-((hydroxyimino)methyl)-1h-imidazol-1-yl)propyl)-1h-1,2,3-triazol-4-yl)methyl)acetamide], c [2-(hydroxyimino)-n-((1-(4-(2-((hydroxyimino)methyl)-1h-imidazol-1-y...

The short and long term effects of chromium toxicity on brain catecholamines and acetylcholinesterase levels were investigated. Rats were injected daily with varying amounts of chromium. The short term (2 h) administration of chromium (8 mmol/kg) reduced catecholamines level of cerebellum, mid-brain and brain-cortex by 22.8, 19.4 and 21.2% respectively. Acetylcholinesterase activity was also re...