The presence of enzymes in mammalian blood which hydrolyze acetylcholine was first suspected by Dale (1)) and later demonstrated by Plattner (2) and by Engelhart and Loewi (3). A serum cholinesterase isolated by Stedman et al. (4) from horse blood was first thought to be the same as the cholinesterase in the central nervous system.’ Distinct differences between the cholinesterase of erythrocyte...

organophosphorous (op) pesticides are used frequently in agriculture, particularly in asian countries over the past decades. poisoning by these agents, either as acute or chronic in these nations, is a serious health problem. op pesticides residue in fruits and vegetables that may not induce early clinical features, could also affect the human health. therefore, medical and health professionals...

The turnover number of acetylcholinesterase is of special interest because the enzyme is thought to be one of the fastest enzymes and because a high speed is a prerequisite for the role of the enzyme in nervous function (1). The earliest value of the turnover number was given by Rothenberg and Nachman sohn (2) in terms of the molecular weight for enzyme obtained from electric eel. The molecular...

In this work, deep eutectic solvents (DES-based menthol and cholinium chloride) the ethanol, temperature, times were selected to extract bioactive compounds from rhizome, leaves, flowers Curcuma longa L., using ultrasound-assisted extraction. Analyzes antioxidant, flavonoids, antimicrobial, chelation Fe2+, inhibition of cholinesterase's enzymes, cytotoxicity, genotoxicity in Allium cepa cells p...

The cerebrospinal fluid (CSF) of normal humans contains both true and pseudocholinesterases and choline acetyl transferase (choline acetylase) detectable by radiochemical assay. Elevations of total cholinesterase, pseudocholinesterase, and true cholinesterase occur in brain tumors, meningitis, Guillain-Barre disease, hydrocephalus, and brain abscess. However, the non-specificity and inconstancy...

Aim & objective: The aim of this study was to evaluate acetyl cholinesterase inhibitory activity of Acacia catechu ethanolic seed extract to introduce a new source for management of Alzheimer’s disease. Background: Alzheimer’s disease is a complex, multifactorial, progressive, neurodegenerative disease primarily affecting the elderly population and is estimated to account for 50–60% of dementia...

Myasthenia gravis is a disorder of impaired neuromuscular transmission resulting in weakness and abnormal fatigability on exertion, improved by anti-acetyl cholinesterase drugs. A number of drugs are known to exacerbate myasthenia gravis or interfere with neuromuscular transmission. We report a case of D-penicillamine induced myasthenia gravis who developed ptosis, diplopia and easy fatigabilit...

To explore the effect of vitamin B1 on Diabetic Peripheral Neuropathy (DPN) and its mechanism for providing a theoretical basis for clinical prevention and effective treatment of diabetic neuropathy. 40 SD male rats were randomly divided into four groups (n=10/group) and they were normal control (NC) group, Diabetes Mellitus (DM) group, diabetic peripheral neuropathy (DPN) group and vitamin B1 ...

In the present study, a series of N-substituted derivatives of 2-phenylethylamine has been synthesized. The reaction of 2-phenylethylamine (1) with benzene sulfonyl chloride (2) yielded N-(2-phenylethyl) benzenesulfonamide (3), which further on treatment with alkyl/acyl halides (4a-i) in the presence of sodium hydride furnished into N-substituted sulfonamides (5a-i). These derivatives were cha...

伴 隆志 ・永田 親 義 The inhibition of cholinesterase by some of carbamates has attracted the attention of many researchers in relation to the clinical usefulness (1) and insecticidal activity (2, 3) of the compounds. In this paper the author's chief concern is mainly devoted to investigating the rela tionship between the electronic structure of several structurally related carbamate type cholinesteras...