We disclose a general two-step procedure to access hitherto unknown and under explored 5- 6-alkynyl-3-fluoro-2-pyridinamidoximes from 6-bromo-3-fluoro-2-cyanopyridines wide range of easily available bench-stable terminal alkynes, using Sonogashira cross-coupling, as the first step. The generation polar amidoxime group is realized at late stage upon treatment alkynylfluorocyanopyridine by hydrox...

Supplementary Material Available: Preparative methods for the starting materials, stereochemical assignments of 1,3-diols listed in Table I, and 400-M Hz 'H N M R spectra of acetonides of 1-3 and 7 (6 pages). Ordering information is given on any current masthead page. The Cytochrome P-450 dependent monooxygenases are mem­ brane-bound enzymes that catalyze a great variety of reactions, among whi...