CONTEXT AND OBJECTIVE Several studies in developed countries have documented that a significant percentage of children are given inappropriate doses of acetaminophen and ibuprofen. The objective of this paper was to investigate parents' accuracy in giving dipyrone and acetaminophen to their children, in a poor region. DESIGN AND SETTING Cross-sectional study at the pediatric emergency departm...

conclusions these data suggest that am404’s concentration-time profile in the brain is similar to those of acetaminophen and its other metabolites. measurement of blood acetaminophen concentration seems to reflect the concentration of the prospective bioactive substance, am404. results the maximum plasma concentrations of acetaminophen and am404 in the rat brain were 15.8 µg/g and 150 pg/g, res...

OBJECTIVE To determine, on the basis of published studies, the efficacy of rectal vs oral acetaminophen as treatment of fever and pain. DATA SOURCES MEDLINE, PubMed, and the Cochrane database as well as major pharmacologic textbooks and the references of all included studies were searched for studies comparing oral and rectal administration of acetaminophen. STUDY SELECTION Randomized and q...

OBJECTIVE To compare the performance of ibuprofen vs codeine for postoperative pain management after tonsillectomy as measured by need for emergency department (ED) treatment for pain and/or dehydration. STUDY DESIGN Retrospective case series with chart review. SETTING Tertiary children's hospital. SUBJECTS AND METHODS Consecutive series of patients who underwent tonsillectomy with or wit...

Importance Acetaminophen (paracetamol) is used by a large proportion of pregnant women. Research suggests that acetaminophen use in pregnancy is associated with abnormal fetal neurodevelopment. However, it is possible that this association might be confounded by unmeasured behavioral factors linked to acetaminophen use. Objective To examine associations between offspring behavioral problems a...

Introduction: Adenotonsillectomy is the main treatment for symptomatic tonsillar hypertrophy with postoperative pain as the most common associated complication. The present study aimed to compare the efficacy of gabapentin with that reported for acetaminophen on the postoperative pain of adenotonsillectomy in children.   Materials and Methods: In this double-blind clinic...

BACKGROUD The main advantage of laparoscopic surgery is that it is minimally invasive because of the use of small incisions. An approach using small incisions offers many benefits including attenuation of surgical wound pain. However, the presence of postoperative pain may undermine the advantages of laparoscopic surgery as a minimally invasive technique. In addition, perioperative pain managem...