The aim of the present study was to investigate the potential of a nanoemulsion formulation for topical delivery of aceclofenac. Various oil-in-water nanoemulsions were prepared by the spontaneous emulsification method. The nanoemulsion area was identified by constructing pseudoternary phase diagrams. The prepared nanoemulsions were subjected to different thermodynamic stability tests. The nano...

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that exhibits analgesic, antipyretic and anti-inflammatory activities. It is practically insoluble in water. The effect of hydrotropes such as urea and sodium citrate and blends (urea + sodium citrate) on the solubility of aceclofenac was investigated. The enhancement in the solubility of aceclofenac was more than 5 and 25 folds in 3...

PURPOSE To evaluate the analgesic effect, efficacy and safety of aceclofenac controlled release (CR) in patients with chronic knee osteoarthritis (OA). MATERIALS AND METHODS A total of 125 subjects with chronic knee OA were randomly divided into two groups: one group (n=62) was administered aceclofenac CR once daily and the other (n=63), aceclofenac immediate release (IR) twice a day for 4 we...

The purpose of this study was to prepare and characterize microspheres loaded by Aceclofenac. To achieve this goal Chitosan and Sodium alginate microspheres loaded by Aceclofenac were prepared by emulsification and ionic gelation methods. Morphology, size, encapsulation efficiency and drug release from these microspheres were evaluated. Microscopic evaluation of microspheres showed that microsp...

The objective was to compare the incidence of adverse reactions reported with three nonsteroidal anti-inflammatory drugs with different cyclo-oxygenase (COX)-2 selectivity. All spontaneous adverse reaction notifications in the pharmacovigilance database of the World Health Organisation Collaborating Centre for International Drug Monitoring with aceclofenac, meloxicam, and rofecoxib that were re...

OBJECTIVE Osteoarthritis is one of the most common forms of arthritis seen in primary care. Non-steroidal anti-inflammatory drugs (NSAIDs) play an important role in the management of osteoarthritis. However, gastrointestinal (GI) side effects limit their use. Cyclooxygenase-2 (COX-2) selective inhibitors exhibit better GI tolerability than conventional NSAIDs, but their cardiovascular safety is...

A simple Reverse phase liquid chromatographic method has been developed and subsequently validated for simultaneous determination of Diacerein and Aceclofenac in combination. The separation was carried out using a mobile phase consisting of dipotassium hydrogen phosphate buffer of pH 4.5, Acetonitrile and methanol in the ratio of 40: 40: 20. The column used was Phenomenex Luna C18, 5μ, 250 mm ×...

A rapid and sensitivity RP-HPLC method was proposed for the qualitative and quantitative estimation of Aceclofenac in dosage form. Aceclofenac had been chromatographed on a C18 column with a mobile phase buffer pH 5.0 and Acetonitrile in the ratio of 60:40v/v. The mobile phase was pumped at a flow rate 1ml/min. Etoricoxib was used as internal standard and elutents were monitored at 275nm. The r...

To the Editor: We read with great interest the article entitled, “A Case of Acute Myocardial Infarction Induced by Selective Cyclooxygenase-2 Inhibitor” by Seo et al.[1] The authors have shown a correlation of aceclofenac intake with the myocardial infarction. This is really important information to be noted as aceclofenac or any nonsteroidal anti-inflammatory drugs (NSAIDS) of this group were ...

The current study involves the evaluation of factors that influence the transcorneal permeation of aqueous drops of aceclofenac ophthalmic formulation through freshly excised goat, sheep, and buffalo corneas. Aceclofenac formulation with different concentrations 0.1-0.5% (w/v) and with different pH and different preservatives, was taken into account. The amount of drug permeated from different ...