Diffusion, partitioning, and binding of two aldose-reductase inhibitors (ARI) in the rat lens were investigated under in vitro conditions. A lipophilic ARI (CT-112) and a hydrophilic ARI (AD-5467) were used as model drugs. Under lens-uptake conditions, the drug concentration in the lens increased rapidly during the initial 10 hr and reached steady state (equilibrium) after 24 hr. Despite the eq...

Access to healthcare is essential in the pursuit of universal health coverage. Components of access are availability, accessibility (spatial and non-spatial), affordability and acceptability. Measuring spatial accessibility is common approach to evaluating access to health care. This study aimed to determine the availability and spatial accessibility of subsidised mammogram screening in Peninsu...

Background: despite the fact that the genetic basis of schizophrenia has been intensively studied for more than two decades, our contemporary knowledge in this field is rather fractional, and a substantial part of it is still missing. The aim of this review article is to sum up the data coming from genome ‐wide association genetic studies in schizophrenia, and indicate prospective directions of...

an eight ‐month ‐old male child was admitted with weakness and swelling in the feet. paraparesis and bilateral lower extremity edema were present in the neurological examination. thoracic MRi showed an intradural intramedullary mass 61 × 11 mm in size in the t5–t10 levels. laminotomy between the t5–t10 vertebrae was performed. a mass with smooth borders was separated from most of the neural tis...

The reactivating and therapeutic efficacy of two combinations of oximes (HI ‐6 + trimedoxime and HI ‐6 + K203) was compared with the effectiveness of antidotal treatment involving single oxime (hi ‐6, trimedoxime, K203) using in vivo methods. In vivo determined percentage of reactivation of cyclosarin ‐inhibited blood and tissue acetylcholinesterase in poisoned rats showed that the reactivating...

COPD is a chronic multisystem disorder with various co morbidities. Smoking is a major risk factor. It’s etiology and multisystem effects may contribute to depression and anxiety. Interplay of various factors along with gender, socioeconomic, educational and marital status also do contribute to depression and anxiety in COPD. Unfortunately, Evaluation of anxiety and depression are often neglect...

Diet can significantly influence athletic performance, but recent research developments have substantially changed our understanding of sport and exercise nutrition. Athletes adopt various nutritional strategies in training and competition in the pursuit of success. The aim of training is to promote changes in the structure and function of muscle and other tissues by selective modulation of pro...