OBJECTIVE To compare pathogenicity of an emergent abortifacient Campylobacter jejuni (IA 3902) with that of reference strains after oral inoculation in pregnant guinea pigs. ANIMALS 58 pregnant guinea pigs. PROCEDURES 12 animals were challenged IP with C jejuni IA 3902 along with 5 sham-inoculated control animals to confirm abortifacient potential. Once pathogenicity was confirmed, challeng...

background: the abortifacient claim of senna alata (s. alata) was scientifically validated recently with alkaloids speculated to be the bioactive agent. this speculation is yet to be substantiated or refuted by scientific evidence. the present study was aimed to investigate the pregnancy terminating effects of the alkaloids from s. alata leaves. methods: twenty four pregnant rats (143.99±1.21 g...

Heterologous antisera were raised by inoculation of rabbits with fairly pure suspensions of trophoblast, lymphoid, fetal (excluding placental components), epidermal, decidual, and renal cells from Fischer rats. After absorption of hemagglutinins, these antisera were assayed for abortifacient activity by intramuscular inoculation into time-mated Fischer females. The anti-trophoblast serum aborte...

BACKGROUND The practice of traditional medicine for the control of fertility in rural Ethiopia is based on folk use of numerous antifertility herbs and Achyranthes aspera is one of these used for this purpose. Many plants are known to possess anti-fertility effect through their action on hypothlamo-pituitary-gonadal axis or direct hormonal effects on reproductive organs resulting in inhibition ...

Consumption of ponderosa pine needles causes late-term abortions in cattle and is a serious poisonous plant problem in foothill and mountain rangelands. Isocupressic acid (IA) is the component of pine needles responsible for the abortifacient effect, its abortifacient effect may be due to inhibition of steroidogenesis. To investigate the more detail molecular mechanism, we used MA-10 cell, whic...

To evaluate the potential abortifacient activity of the aqueous, alcohol, ethyl acetate and chloroform extracts of P. rubra pod in female albino rats 50, 100 and 200 mg/kg body weight doses of each extract were administered from day 11 to 15 of pregnancy and animals were allowed to go full-term. The phytochemical screening revealed the presence of alkaloids, flavonoids, simple phenolics, steroi...