نتایج جستجو برای: aaph

تعداد نتایج: 218  

Journal: :iranian journal of pharmaceutical sciences 0
gholamreza karimi department of pharmacology and toxicology, faculty of pharmacy, mashhad university of medical sciences, mashhad, iran mohammad hassanzadeh department of pharmacology and toxicology, faculty of pharmacy, mashhad university of medical sciences, mashhad, iran soghra mehri department of pharmacology and toxicology, faculty of pharmacy, mashhad university of medical sciences, mashhad, iran

the oxidative hemolysis of rat erythrocytes induced by 2,2’-azobis–(2-amidinopropane) (aaph) and its inhibition by rosemary essential oil was studied. different concentrations (0.178, 0.357, 0.534 and 0.712 ml/ml) of the essential oil showed no significant hemolysis compared to phosphate buffer solution. aaph (25 mm and 50 mm) induced hemolysis in a time-dependent manner. diff e r e n t concent...

2017
Yasukiyo Yoshioka Xiu Li Tianshun Zhang Takakazu Mitani Michiko Yasuda Fumio Nanba Toshiya Toda Yoko Yamashita Hitoshi Ashida

Black soybean seed coat extract (BE), which contains abundant polyphenols such as procyanidins, cyanidin 3-glucoside, (+)-catechin, and (-)-epicatechin, has been reported on health beneficial functions such as antioxidant activity, anti-inflammatory, anti-obesity, and anti-diabetic activities. In this study, we investigated that prevention of BE and its polyphenols on 2,2'-azobis(2-methylpropio...

2016
An-Chen Guo Yi-Long Zhao Yong-Jun Wang Qun Wang

Cattle encephalon glycoside and ignotin injection offers neural protection after cerebral apoplexy clinically, but the exact mechanism of the protective effect is unclear. We performed primary culture of neurons and astrocytes and simulated ischemic brain damage using AAPH and discussed the action mechanism of cattle encephalon glycoside and ignotin injection. Results showed that cattle encepha...

Journal: :Botany 2021

In this study, we characterized how lipid peroxidation alters the functionality of spinach thylakoids exposed to peroxyl radicals generated by azo compound 2,2-azobis(2-amidinopropane) dihydrochloride (AAPH). Incubation in presence different concentrations (0 200 mmol·L –1 ) AAPH inhibited formation ?pH (IC 50 ? 1.5 estimated quenching 9-aminoacridine fluorescence (Q9-AA). The Q9-AA inhibition ...

Journal: :Free radical research 2003
Steven P Gieseg Joseph Pearson Carole A Firth

Damage to apoB100 on low density lipoprotein (LDL) has usually been described in terms of lipid aldehyde derivatisation or fragmentation. Using a modified FOX assay, protein hydroperoxides were found to form at relatively high concentrations on apoB100 during copper, 2,2'-azobis(amidinopropane) dihydrochloride (AAPH) generated peroxyl radical and cell-mediated LDL oxidation. Protein hydroperoxi...

Journal: :Toxicology in vitro : an international journal published in association with BIBRA 2015
Thaisa Baccarin Montserrat Mitjans Elenara Lemos-Senna Maria Pilar Vinardell

The main purpose of the present study is to evaluate the ability of nanoemulsion entrapping pomegranate peel polyphenol-rich ethyl acetate fraction (EAF) prepared from pomegranate seed oil and medium chain triglyceride to protect human erythrocyte membrane from oxidative damage and to assess preliminary in vitro photosafety. In order to evaluate the phototoxic effect of nanoemulsions, human red...

Journal: :Biochimica et biophysica acta 2005
M Stefek Z Kyselova L Rackova L Krizanova

In an attempt to model the processes of free radical-mediated cataractogenesis, we investigated the oxidative modification of rat eye lens proteins by peroxyl radicals generated by thermal decomposition of 2,2'-azobis(2-amidinopropane)hydrochloride (AAPH) under aerobic conditions. When incubated with AAPH, the soluble eye lens proteins precipitated in a time-dependent manner. The insolubilisati...

Journal: :The Biochemical journal 1996
M Minetti D Pietraforte A M Di Stasi C Mallozzi

Previous studies have demonstrated that glyceraldehyde-3-phosphate dehydrogenase (GAPDH) undergoes NAD(H) linkage to an active site thiol when it comes into contact with .NO-related oxidants. We found that a free-radical generator 2,2'-azobis-(2-amidinopropane) hydrochloride (AAPH), which does not release either .NO or .NO-related species, was indeed able to induce the NAD(H) linkage to GAPDH. ...

Journal: :Journal of nutritional science and vitaminology 2005
Xiang Lan Piao Hyun Young Kim Takako Yokozawa Young A Lee Xiang Shu Piao Eun Ju Cho

The radical scavenging effect and protective potential from oxidative damage by radical generator, 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH), in renal epithelial LLC-PK1 cell of broccoli (Brassica oleracea) were investigated and identified the active components under the bioassay-linked fractionation method. The MeOH extract, and fractions of CH2Cl2, BuOH and H2O from broccoli showe...

Journal: :Acta biochimica Polonica 2010
Maria Juskova Vladimir Snirc Ludmila Krizanova Milan Stefek

Recently novel carboxymethylated pyridoindoles, analogues of the efficient chain-breaking antioxidant stobadine, have been designed, synthesised and characterised as bifunctional compounds with joint antioxidant/aldose reductase inhibitory activities with the potential of preventing diabetic complications. The critical property for the efficacy of the novel aldose reductase inhibitors in vivo i...

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