نتایج جستجو برای: a14
تعداد نتایج: 350 فیلتر نتایج به سال:
Previous research identified a locus on Chromosome 14 as an important regulator of endurance exercise capacity in mice. The aim of this study was to investigate the effect of chromosome substitution on intrinsic exercise capacity and identify quantitative trait loci (QTL) associated with exercise capacity in mice. Mice from a chromosome substitution strain (CSS) derived from A/J and C57Bl/6J (B...
A series of 1,3-benzoazole derivatives possessing amide moieties were designed, synthesized and evaluated as inhibitors against human dihydroorotate dehydrogenase (hDHODH). Compounds A11, A14 and A26 exhibited good to excellent activities against hDHODH at the concentration of 10μM. In particular, compound A14 displayed an IC50 value of 0.178μM with 2-fold preference over A771726. The result im...
We have used two methods for the preparation of a highly homogeneous insulin with high specific activity. After iodination with chloramine T, the labeled peptides were retained on a disposable Sep Pak cartridge and subsequently eluted. The eluted labeled insulins were further purified by either DEAE cellulose or high performance liquid chromatography (HPLC) to separate A14-125I- from A19-125I-i...
This research included synthesizing a series of heterocyclic compounds where the compound 2-chloroacetohydrazide was synthesized from ethyl chloroethanoate with Hydrazine hydrate 95%. The reaction carried out in cold condition. 2-(pyrimidin-2-ylamino)acetohydrazide prepared by A1 2-amino pyrimidine absolute ethanol using Potassium hydroxide (KOH); then 2-(pyrimidin-2-ylamino) acetohydrazide dif...
G12 rotaviruses are emerging rotavirus strains causing severe diarrhea in infants and young children worldwide. However, the whole genomes of only a few G12 strains have been fully sequenced and analyzed. In this study, we sequenced and characterized the complete genomes of six G12 strains (RVA/Human-tc/MMR/A14/2011/G12P[8], RVA/Human-tc/MMR/A23/2011/G12P[6], RVA/Human-tc/MMR/A25/2011/G12P[8], ...
Coated platelets, formed by collagen and thrombin activation, have been characterized in different ways: i) by the formation of a protein coat of α-granular proteins; ii) by exposure of procoagulant phosphatidylserine; or iii) by high fibrinogen binding. Yet, their functional role has remained unclear. Here we used a novel transglutaminase probe, Rhod-A14, to identify a subpopulation of platele...
In 1975, McKusick1 first mentioned a syndrome of ulnar ray defects and genital abnormalities, citing a personal communication from A Schinzel (1973), and named it 'Schinzel syndrome' (McKusick No 18145) in this and in all subsequent editions of his catalogue.2 One year later, Pallister et a13 and Gonzales et a14 described the same syndrome in two families, and the latter authors named the syndr...
Synthesis of ribosomal RNA (rRNA) by RNA polymerase (Pol) I is the first step in ribosome biogenesis and a regulatory switch in eukaryotic cell growth. Here we report the 12 A cryo-electron microscopic structure for the complete 14-subunit yeast Pol I, a homology model for the core enzyme, and the crystal structure of the subcomplex A14/43. In the resulting hybrid structure of Pol I, A14/43, th...
Acne vulgaris is a disorder affecting the pilosebaceous unit resulting in both inflammatory and non-inflammatory clinical lesions. Cutibacterium acnes (C. acnes) of specific lineage, plays key role acne by producing several virulence factors thereby increasing their capacity. The C. mutated CAMP1 factor display strong TLR-2 binding property highly strains. peptide array analysis 116 15-mer pept...
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