In 82% of cows, contamination the genitals with conditionally pathogenic microflora E. coli was established in 17% cases, S. aureus - 15%, P. mirabilis 14%, pyogenes pyogenes, R. vulgaris, C. albicans 14.0%; aureus, coli, mirabilis, albicans, A. fumigatus, M. racemosus 12% cases latent endometritis. salpingitis, microorgans were isolated association 28.5% cases; 27.7% fumigatus 25.2%; 13.1%, re...

New 1,2,4-triazoles (2) having a difluoro(substituted sulfonyl)methyl moiety were designed and synthesized via alpha,alpha-difluoro-alpha-(substituted thio)acetophenones (3). Compounds (2) showed potent antifungal activities against C. albicans, C. krusei, A. flavus and A. fumigatus in vitro and against C. albicans in vivo for oral and i.v. administrations. Especially, (-)-2a, (-)-2b and (-)-2d...

Carrichtera annua a plant belonging to family Brassicaceae was selected be evaluated for its antimicrobial activity against number of microorganisms. The powdered extracted with ethanol until exhaustion. concentrated extract tested fungi, gram positive and gram-negative bacteria. results revealed that the showed significant promising towards Aspergillus fumigatus, Proteus vulgaris, Enterococcus...

Previous studies have suggested that endogenous protease inhibitors may participate in the mucosal host defense. Antileukoprotease (ALP) is an important protease inhibitor found on various mucosal surfaces, including those of the respiratory and genital tracts. This study reports on the antimicrobial activity of recombinant (r) ALP toward the human fungal pathogens Aspergillus fumigatus and Can...

We investigated the antifungal activities of itraconazole and voriconazole on Aspergillus species by time kill studies, and the results were compared with those obtained for Candida species. Exposure of Aspergillus fumigatus conidia to varying concentrations (1.25 to 10 microg/ml) of itraconazole and voriconazole resulted in cellular death; the cytocidal effect was time and concentration depend...

Ficus congensis (Moraceae) is used traditionally in the treatment of various diseases including infectious diseases, infertility, and gastrointestinal disorders. Investigation of hexane extract of the stem bark using chromatographic techniques led to isolation of a xanthone, 1-hydroxy-3,7,8-trimethoxyxanthone (Decussatin). The compound was elucidated based on spectroscopic methods such as nucle...

Introduction: Increasing rate of candidiasis prevalence and consequently use of antifungal drugs as prophylactic and curative agents has led to the widespread emergence of resistant strains. Therefore this study was designed to evaluate the in vitro antifungal activity of an aqueous extract of garlic and the synergic effect of garlic extract with fluconazole against common clinical isolates of ...

2-Deoxy-D-glucose-6-phosphate ketol-isomerase (EC 2.6.1.16) forms glucosamine-6-phosphate and glutamate from fructose-6-phosphate and glutamine and plays an important role in chitin synthesis in fungi. We have established a new assay for fungal ketol-isomerase activity that is amenable to high throughput screening to identify enzyme inhibitors. Aspergillus fumigatus crude lysate was incubated w...

Introduction: Cinnamon zeylanicum is used for various medical purposes. The aim of this study was to compare the antifungal efficacy of cinnamon and amphotericin B against Candida species in vitro. Material & Methods: Candida albicans (C. albicans) and Candida krusei (C. Krusei) were obtained from the Iranian Industrial and Scientific Research Center. The minimum inhibitory concentration (MIC)...