OBJECTIVE Chemical reactions involved in preparing 99mTc radiopharmaceuticals occasionally result in products of substandard purity. A retrospective examination of preparation problems that occurred in the author's institution was conducted to better define the incidence, recognize patterns and identify causes of substandard 99mTc radiopharmaceutical products. METHODS All 99mTc radiopharmaceu...

Background: Hot lab is a specially designed room in a nuclear medicine hospital where the radiopharmaceuticals are delivered, stored and prepared for dispensing. 99Mo/99mTc-generator is the major source in the hot lab used for various medical imaging. It is important to maintain a standard for hot lab procedures to optimize the patient care and minimize radiation exposure to all nuclear medicin...

OBJECTIVE Measurement of cardiac perfusion via agents such as 99mTc-sestamibi (Cardiolite; DuPont-Merck Pharmaceutical Co., Inc.) is widely used in clinical nuclear medicine for the diagnosis of coronary artery disease. The monograph for 99mTc-sestamibi recommends at least 90% radiochemical purity (RCP) for clinical use. Various factors may influence the RCP of certain reagent kits. Some of the...

Technetium is an element that is artificially produced and all its isotopes are radioactive. Several investigations have been performed on the subject of the production of Tc radioisotopes using cyclotrons. Among these radioisotopes, 99mTc with a half-life of 6.02 h and gamma-ray spectrum with an energy peak at 140.5 keV has a vast application in nuclear medicine. More than 85% of administered ...

background: local ablative treatments play an important role for patients who cannot be treated surgically. radiofrequency ablation is a well-established alternative to surgical treatment of thyroid nodules, however it also has disadvantages. microwave ablation (mwa) is a new minimally invasive treatment promising several improvements. the aim of this retrospective study was to evaluate the eff...

Background: Local ablative treatments play an important role for patients who cannot be treated surgically. Radiofrequency ablation is a well-established alternative to surgical treatment of thyroid nodules, however it also has disadvantages. Microwave ablation (MWA) is a new minimally invasive treatment promising several improvements. The aim of this retrospective study was to evaluate the eff...

Technetium-99m (99mTc) is one of the most desirable radionuclides for external imaging in diagnostic nuclear medicine, due to the emission of gamma ray of optimal energy (140 keV), a suitable half-life (6 h), and availability from 99Mo-99mTc generator systems. In addition, development of 99mTc radiopharmaceuticals for tumor imaging paves the way for therapeutic radiopharmaceuticals with high en...

background: 99mtc is a widely used radioisotope in nuclear medicine centers which is obtained by elution from mo-99/tc-99m generators. usually the generators are either supplied by the iran atomic energy agency or by private companies from foreign countries. in this study we have measured 99mo contamination in 99mtc elute from different generators in a period of one year. materials and methods:...

Background: 99mTc is a widely used radioisotope in nuclear medicine centers which is obtained by elution from Mo-99/Tc-99m generators. Usually the generators are either supplied by the Iran Atomic Energy Agency or by private companies from foreign countries. In this study we have measured 99Mo contamination in 99mTc elute from different generators in a period of one year. Materials and...

99mTc-Macroaggregated Albumin (99mTc-MAA) has been used as a perfusion agent. This study described development of the 68Ga-MAA via commercially available kits from Pars-Isotopes Company as a 99mTc-MAA kit. 68Ge/68Ga generator was eluted with suprapure HCl (0.6 M, 6 mL) in 0.5 mL fractions. The two fractions with the highest 68GaCl3 activity were generally used for labeling purposes. After label...