A 73-year-old male was diagnosed with clear-cell renal carcinoma in 2002. He had right nephrectomy, developing thereafter metastases in both adrenal glands and in the right gluteus region. He received immunotherapy and remained with stable diseases until august 2011, when suddenly unfold an unstable condition, developing a renal failure with elevation of creatinine levels and need of dialysis. ...

99m The use of Tc-DTPA is for brain imaging renal flow study, and glomerular filtration rate measurement. Following intravenous injection, 99mTc-DTPA is rapidly cleared from the blood by glomerular filtration. Renal retention is 7% of the injected dose at 1 h and 95% is excreted within 24 h. It is neither secreted nor reabsorbed by the tubules and has negligible biliary excretion and eliminatio...

introduction: renal dynamic study is a well-established and popular test in routine practice of nuclear medicine. the test is non-invasive, rapid and unique in evaluation of the kidney function. in despite of its clinical values, the parameters derived from renogram are physiologically meaningless. that is due to the fact that renogram is not the true kidney function. from mathematical points o...

Based on the previous demonstration of a renoprotective effect of arginine-glycine-aspartic acid (RGD) peptides in acute renal failure, experiments were designed to test the distribution and renal accumulation of the peptide. To accomplish this goal, in this study, RGD peptide was radiolabeled and its biodistribution and renal accumulation was determined in rats with ischemic acute renal failur...

Introduction: Clinical radiation nephropathy can result in considerable morbidity and/or mortality. Renal tolerance (TD5/5) has been stated to be 20 Gy when irradiation has been delivered to both kidneys in 3-5 weeks. Therefore to minimize renal toxicity in these patients, localization and shielding of the kidneys are essential. This study was carried out to evaluate the role of 99mTc-DTP...

Objective: Congenital hydronephrosis is a common prenatally diagnosed anomaly associated with an incidence of approximately 0.5-1% in newborns. The purpose of this study was to clarify the value of 99 m diethylenetriamine pentaacetic acid (99mTc-DTPA) in the assessment of renal function impairment of pediatric hydronephrosis. Methods: A total of 48 children with unilateral ureteropelvic junctio...

UNLABELLED Antibodies accumulate nonspecifically in infectious foci due to the locally increased vascular permeability. This study describes a method of infection imaging in which 99mTc-DTPA (diethylenetriaminepentaacetic acid) is trapped at the target by a previously administered anti-DTPA monoclonal antibody. DTIn1. METHODS Rats with Staphylococcus aureus-infected calf muscle were injected ...

Forty-seven patients with unilateral obstructive calculi (12 males and 35 females) were submitted to 99mTc-diethylene triamine pentaacetic acid (DTPA) or 99mTc-dimercaptosuccinic acid (DMSA) scans for assessment of renal function. The scans revealed unilateral functional deficit in 68 and 66% of the patients, respectively. A calculus size of 1.1 to 2.0 cm was significantly associated with defic...

A three-dimensional magnetic resonance (MR) renographic method to measure single kidney glomerular filtration rate (GFR) and split renal function was developed that is based on renal signal intensity measurements during 2-3 minutes after intravenous injection of a low dose (2 mL or 0.01 mmol/kg) of gadopentetate dimeglumine. In nine subjects, single kidney MR GFR indices correlated well with te...