نتایج جستجو برای: 963
تعداد نتایج: 1023 فیلتر نتایج به سال:
INTRODUCTION......... . ...... ................. .. ................. . .... . . ................. ......... 933 NOTIONS ABOUT RECOGNITION..... ................ . . .............. . . ..... . ......... . . ..... 934 THE HTH MOTIF... ..... ....... ................. .. . ................ .... . . .... ........... . .. . ..... .. 936 STRUCTURES.... . . . ..... .. ......... . . ................ ......
Nonsteriodal anti-inflammatory drugs (NSAIDs) are efficacious for the treatment of pain associated with inflammatory disease. Clinical experience with marketed selective cyclooxygenase-2 (COX-2) inhibitors (celecoxib, rofecoxib, and valdecoxib) has confirmed the utility of these agents in the treatment of inflammatory pain with an improved gastrointestinal safety profile relative to NSAID compa...
http://bjo.bmj.com/content/94/8/963.full.html Updated information and services can be found at: These include: References http://bjo.bmj.com/content/94/8/963.full.html#ref-list-1 This article cites 13 articles, 3 of which can be accessed free at: service Email alerting box at the top right corner of the online article. Receive free email alerts when new articles cite this article. Sign up in th...
(S)-5, 6-Difluoro-4-cyclopropylethynyl-4-trifluoromethyl-3, 4-dihydro- 2-(1H)-quinazolinone (DPC 963), a specific non-nucleoside inhibitor of human immunodeficiency virus-1 reverse transcriptase, is primarily metabolized in humans to the glucuronide conjugate of 8-OH DPC 963 (M8). Electrospray ionization-liquid chromatography/mass spectrometry analyses of urine from subjects dosed with DPC 963 ...
Sergio Castiñeira-Ibáñez 1, Daniel Tarrazó-Serrano 2, Constanza Rubio 2,*, Pilar Candelas 2 and Antonio Uris 2 1 Departamento de Ingeniería Electrónica, Universitat de València, Avd. de la Universitat s/n, Burjassot, Valencia 46100, Spain; [email protected] 2 Centro de Tecnologías Físicas, Universitat Politècnica de València, Camino de Vera s/n, Valencia 46022, Spain; [email protected] (D.T.-S.); ...
Replication-selective oncolytic viruses (virotherapeutics) are being developed as novel cancer therapies with unique mechanisms of action, but limitations in i.v. delivery to tumors and systemic efficacy have highlighted the need for improved agents for this therapeutic class to realize its potential. Here we describe the rational, stepwise design and evaluation of a systemically effective viro...
Vicinally disubstituted pyridazinones act as potent and selective COX-2 inhibitors. Compound, ABT-963, (2-(3,4-difluoro-phenyl)-4-(3-hydroxy-3-methyl-butoxy)-5-(4-methanesulfonyl-phenyl)-2H-pyridazin-3-one) has an excellent selectivity (ratio of 276, COX-2/COX-1), improved aqueous solubility compared with celecoxib and rofecoxib, high oral anti-inflammatory potency and gastric safety in the ani...
INTRODUCTION ................................................................................ 955 I. AVERAGING ................................................................................ 958 II. SHRINKAGE ................................................................................ 960 III. NONRANDOM SAMPLING ............................................................. 963 CONCLUSION ....
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