Our previous study proved that TP53-induced glycolysis and apoptosis regulator (TIGAR) abrogation is able to radiosensitize glioma cells. Whether TIGAR over-expression has radio-protective effect in human parotid gland cells is still unknown. In this study human parotid gland fibroblast Hs 917.T cells were transfected with pcDNA3.1-TIGAR, and clonogenic assay was performed to investigate the ra...

Address correspondence to David W. Good, PhD, Division of Nephrology, 4.200John Seal}' Hospital E62, University of Texas Medical Branch, Galveston, Texas 77555-0562. j. GEN. PHYSIOL. 9 The Rockefeller University Press 9 0022-1295/94/05/0917/20 $2.00 Volume 103 May 1994 917-936 917 on F ebuary 3, 2013 jgp.rress.org D ow nladed fom Published May 1, 1994

Department of Biochemistry, Faculty of Medicine, The Hebrew University, 91120 Jerusalem, Israel Spanish National Cancer Institute (CNIO), Melchor Fernandez Almagro, 3, E-28029 Madrid, Spain Corresponding author. Tel: +972 2 675 7528; Fax: +972 2 675 7379; E-mail: [email protected] Corresponding author. Tel: +34 917 328 000; Fax: +34 912 246 980; E-mail: [email protected] Corresponding author...

Trans-Dehydrocrotonin, a 19-nor-clerodane, is the major norditerpene obtained from Croton cajucara, a Brazilian medicinal plant which presents important biological effects, such as antineoplastic and antiulcerogenic activities. In this work, we analyzed the effect of this sesquiterpene lactone on normal human lymphocytes. The cell viability was verified after treatment for 24 and 72 h with tran...

During nitric oxide signaling, type Ialpha cGMP-dependent protein kinase (PKGIalpha) activates myosin light chain (MLC) phosphatase through an interaction with the 130-kDa myosin targeting subunit (MYPT1), leading to dephosphorylation of 20-kDa MLC and vasodilatation. It has been suggested that the MYPT1-PKGIalpha interaction is mediated by the COOH-terminal leucine zipper (LZ) of MYPT1 and the...

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[This corrects the article on p. 917 in vol. 9, PMID: 27826214.].