Epidemiological studies have demonstrated that ginseng intake decreases the risk of cancer. Ginseng saponins (ginsenosides) have been regarded as principal components responsible for the majority of pharmacological activities exerted by ginseng. IH-901 [20-O-beta-d-glucopyranosyl-20(S)-protopanaxadiol], an intestinal bacterial metabolite derived from protopanaxadiol-type saponins of Panax ginse...

1Department of Biological Science, Okinawa Prefectural Institute of Health and Environment, Okinawa 901-1202; 2Awase Daiichi Clinic, Okinawa 904-2172; 3Aozora Pediatric Clinic, Okinawa 901-1302; 4Gushi Kodomo Clinic, Okinawa 901-0244; 5Gunma Prefectural Institute of Public Health and Environmental Sciences, Gunma 371-0052; and 6Infectious Disease Surveillance Center, National Institute of Infec...

1 ToxTrac: a fast and robust software for tracking organisms Alvaro Rodriquez, Hanqing Zhang, Jonatan Klaminder, Tomas Brodin, Patrik L. Andersson, Magnus Andersson Department of Physics, Umeå University, 901 87 Umeå, Sweden, Department of Ecology and Environmental Science, Umeå University, 901 87 Umeå, Sweden, Department of Chemistry, Umeå University, 901 87 Umeå, Sweden

I-Chan Huang UFCOM [email protected] (352) 265-2514 Wendy Leisenring FHCRC [email protected] (206) 667-4374 Gwendolyn Quinn MCC [email protected] (813) 745-1359 Elizabeth Shenkman UFCOM [email protected] (352) 265-2547 Kelly Kenzik UFCOM [email protected] (352) 265-2572 Mandy Li BC [email protected] (617) 552-4534 Tara Brinkman SJCRH [email protected] (901) 595-5683 Christopher Rec...

a Centre of Post-Graduation and Research in Management, School of Economic Sciences, Federal University of Minas Gerais (UFMG), Antônio Carlos Avenue, 6627, Pampulha, Belo Horizonte, Minas Gerais, 31270‐901, Brazil b Department of Administrative Sciences, School of Economic Sciences, Federal University of Minas Gerais (UFMG), Antônio Carlos Avenue, 6627, Pampulha, Belo Horizonte, Minas Gerais, ...

BACKGROUND Development of a tuberculosis vaccine to boost BCG is a major international health priority. SRL172, an inactivated whole cell booster derived from a non-tuberculous mycobacterium, is the only new vaccine against tuberculosis to have demonstrated efficacy in a Phase 3 trial. In the present study we sought to determine if a three-dose series of DAR-901 manufactured from the SRL172 mas...

Atalay Alem, Lars Jacobsson, Niels Lynöe, Robert Kohn, Gunnar Kullgren* Amanuel Psychiatric Hospital, Addis Ababa, Ethiopia Department of Clinical Sciences, Division of Psychiatry, Umeå University, S-901 85 Umeå, Sweden Department of Nursing, Umeå University, SE-901 87 Umeå, Sweden Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA Department of Clinical Sciences...

From the Department of Plant Physiology and Umeå Plant Science Centre, Umeå University, SE-901 87 Umeå, Sweden Umeå Plant Science Centre, Department of Forest Genetics and Plant Physiology, SLU, SE-901 87 Umeå, Sweden Biochemistry and Physiology of Plants, Faculty of Biology, W5, Bielefeld University, 33501 Bielefeld, Germany Department of Chemistry, Center of Chemical Biology and Computational...

We asked whether inclusion of the FLAG epitope in the fourth extracellular loop of the cystic fibrosis transmembrane conductance regulator (M2-901/CFTR), which permits detection of cell surface expression, affected CFTR's biophysical properties or channel regulation by kinases, phosphatases, and nucleotides. Channel activity of M2-901/CFTR was evaluated in numerous cell types and expression sys...

IT-901 is a novel and selective NF-κB inhibitor with promising activity in pre-clinical models. Here we show that treatment of chronic lymphocytic leukemia cells (CLL) with IT-901 effectively interrupts NF-κB transcriptional activity. CLL cells exposed to the drug display elevated mitochondrial reactive oxygen species, which damage mitochondria, limit oxidative phosphorylation and ATP productio...