ABT-869 [N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea] is a novel multitargeted inhibitor of the vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) receptor tyrosine kinase family members. ABT-869 demonstrates tumor growth inhibition in multiple preclinical animal models and in early clinical trials. VEGF receptor inhibition is also ass...

Gastric cancer, highly dependent on tumor angiogenesis, causes uncontrolled lethality, in part due to chemoresistance. Here, we demonstrate that linifanib (ABT-869), a novel multi-targeted receptor tyrosine kinase inhibitor, markedly augments cytotoxicity of chemotherapies in human gastric cancer. ABT-869 and chemotherapeutic agents exhibited a strong synergy to inhibit the viability of several...

To further investigate potential mechanisms of resistance to FLT3 inhibitors, we developed a resistant cell line by long-term culture of MV4-11 cells with ABT-869, designated as MV4-11-R. Gene profiling reveals up-regulation of FLT3LG (FLT3 ligand) and BIRC5 (survivin), but down-regulation of SOCS1, SOCS2, and SOCS3 in MV4-11-R cells. Hypermethylation of these SOCS genes leads to their transcri...

Hyung-Min Park , Ho-Young Jung , Te-Won Lee , and Soo-Young Lee Department of Electrical Engineering and Brain Science Research Center, Korea Advanced Institute of Science and Technology, 373-1, Kusong-dong, Yusong-gu, Taejon, 305-701, Korea (TEL: +82-42-869-8031, FAX: +82-42-869-8570, E-mail: [email protected]) Computational Neurobiology Laboratory The Salk Institute 10010 N. Torrey Pines...

Rev Esp Cardiol 2004;57(9):869-83 869 Advanced heart failure, also be defined as stage D heart failure, characterized by advanced structural heart disease and marked symptoms of heart failure at rest despite dietary modification, salt restriction and maximal medical therapy including ACE inhibitors, angiotensin II receptor blockers, digitalics, diuretics and beta blockers. These patients requir...

Journal of Research and Practice in Information Technology, Vol. 32, No. 1, February 2000 39 Pet Formalisms versus Industry-Proven Survivors: Issues on Formal Methods Education S.D. Cha Department of Computer Science and Advanced Information Technology Research Centre (AITrc) Korea Advanced Institute of Science and Technology (KAIST) 373–1 Kusong-dong, Yusong-gu Taejon, Korea Phone: 82-42-869-3...

Stroke is one of the three diseases that cause human death in current world, and it is the common, frequently occurring disease in the middle-old ages. NMDA receptors mediate glutamate-induced cell death when intensely or chronically activated, which is an important cause of neuronal cell death after acute injuries. Here, we demonstrated that BQ-869, a potent NMDA receptor antagonist, blocked N...

Substantial laboratory evidence suggests Transforming Growth Factor-beta1 (TGFB1) is linked to Alzheimer's Disease (AD) pathology. The purpose of the study was to estimate the genetic association of TGFB1 with AD while controlling for apolipoprotein E4 allele (APOE4) status, the only well-established genetic risk factor for AD. Two study populations were genotyped for the TGFB1-509 and +869 sin...

Skeleta and other pure subsets of manifold stratified spaces are shown to have neighborhoods which are teardrops of stratified approximate fibrations (under dimension and compactness assumptions). In general, the stratified approximate fibrations cannot be replaced by bundles, and the teardrops cannot be replaced by mapping cylinder neighborhoods. Thus, this is the best possible topological tub...