نتایج جستجو برای: 839
تعداد نتایج: 1134 فیلتر نتایج به سال:
Curative responses in the treatment of multiple myeloma (MM) are limited by the emergence of therapeutic resistance. To address this problem, we set out to identify druggable mechanisms that convey resistance to proteasome inhibitors (PIs; e.g., bortezomib), which are cornerstone agents in the treatment of MM. In isogenic pairs of PI sensitive and resistant cells, we observed stark differences ...
(51) Int. Cl. G06F 3/00 (2006.01) G06F 3/14 (2006.01) (52) U.S. Cl. ...................... 715/839; 715/716; 715/719; 715/764; 715/835; 715/838; 715/500.1; 715/526; 358/540 (58) Field of Classification Search ................ 345/700, 345/716,717,719,727,764,835,838,839, 345/855; 358/1.1,1.15,1.18,530,540; 705/55; 715/479,500,500.1,501.1,513,526,527, 715/700,716,717,719,727,764,835,838, 715/839...
We aim to correlate point mutations in the androgen receptor gene with receptor phenotypes and with clinical phenotypes of androgen resistance. In two families, the external genitalia were predominantly female at birth, and sex-ofrearing has been female. Their androgen receptor mutation changed arginine-839 to histidine. In a third family, the external genitalia were predominantly male at birth...
Three spring wheat germplasm lines (839–984, 841–2, and 839–1076) with resistance to common root rot
......................................................................................................................................................839 Introduction.................................................................................................................................................839 Purpose and Scope ...................................................................
Glutamine serves as an important source of energy and building blocks for many tumor cells. The first step in glutamine utilization is its conversion to glutamate by the mitochondrial enzyme glutaminase. CB-839 is a potent, selective, and orally bioavailable inhibitor of both splice variants of glutaminase (KGA and GAC). CB-839 had antiproliferative activity in a triple-negative breast cancer (...
A search of MEDLINE, Cochrane, and EMBASE databases and conference proceedings (January 1988‒December 2015) were included to evaluate data and select pertinent articles on the topic. Search terms included cryptorchidism or undescended testicle as the topic of interest with an English language limit. Retrospective and prospective study designs, case series, review articles, and consensus stateme...
Zeitschrift für ausländisches öffentliches Recht und Völkerrecht / Heidelberg Journal of International Law , Seite 839 - 844
A series of allosteric kidney-type glutaminase (GLS) inhibitors were designed and synthesized using 1,4-di(5-amino-1,3,4-thiadiazol-2-yl)butane as a core scaffold. A variety of modified phenylacetyl groups were incorporated into the 5-amino group of the two thiadiazole rings in an attempt to facilitate additional binding interactions with the allosteric binding site of GLS. Among the newly synt...
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