Four new purine alkaloids, namely, 6-(1'-purine-6',8'-dionyl)suberosanone ( 1), 3,9-(2-imino-1-methyl-4-imidazolidinone-5-yl)isopropenylpurine-6,8-dione ( 2), 1-(3'-carbonylbutyl)purine-6,8-dione ( 3), and 9-(3'-carbonylbutyl)purine-6,8-dione ( 4), together with three known compounds, guanosine ( 5), thymidine ( 6), and adenosine ( 7), were isolated from the EtOH/CH 2Cl 2 extracts of the South ...

New ytterbium (III) compounds with β-diketones (2,7-dimethyl-octene-1-dione-3,5 and 2,6-dimethylheptene-1-dione-3,5) their derivatives phenanthroline have been synthesized. The composition chemical structure of the obtained complexes determined by several Phy­sico-chemical investigations. It has shown, that Yb ion coordinates three ligand molecules coordination sphere is supplemented two mole­c...

Nanostructured titanium(IV) oxide was used for the destructive adsorption and photocatalytic degradation of mitoxantrone (MTX), a cytostatic drug from the group of anthracycline antibiotics. During adsorption on a titania dioxide surface, four degradation products of MTX, mitoxantrone dicarboxylic acid, 1,4-dihydroxy-5-((2-((2-hydroxyethyl)amino)ethyl)amino)-8-((2-(methylamino)ethyl)amino)anthr...

The formation of the benzo[a]pyrene (B[a]P) diones (B[a]P-1,6-dione, B[a]P-3,6-dione, B[a]P-6,12-dione) as the main products of oxidative degradation of B[a]P has been observed under atmospheric conditions in air particulate matter. Samples were collected at two different sites in Munich, Germany. Total B[a]P dione concentrations were determined by APCI/LC-MS and ranged between 8 and 605 pg m-3...

Polycyclic aromatic hydrocarbons (PAHs) are tobacco carcinogens implicated in the causation of human lung cancer. Metabolic activation is a key prerequisite for PAHs to cause their deleterious effects. Using human lung adenocarcinoma (A549) cells, we provide evidence for the metabolic activation of (+/-)-trans-7,8dihydroxy-7,8-dihydrobenzo[a]pyrene (B[a]P-7,8-trans-dihydrodiol) by aldo-keto red...

A simple, fast and cost-effective three-step synthesis of 1-methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione has been developed. The reactions described herein proceed readily, with high yields no further purification. Therefore, the proposed method, an overall yield 60%, offers a facile pathway to N-1 monosubstituted spiro carbocyclic imidazolidine-2,4-diones (hydantoins), which constitute ...

dna intercalators belong to aromatic heterocyclic compounds interacting reversibly with dna. these compounds have been used extremely as cytotoxic agents against cancer. in this study, the synthesis and biological activity of some novel derivatives of cyclopenta [b] quinoline-1, 8-dione as new intercalating agent were investigated. twenty novel derivatives of cyclopenta [b] quinoline-1, 8-dione...

6-Formyl-7-hydroxy-5-methoxy-2-methylchromone on bromination yields the 8-bromo deriva­ tive or the 8-bromo-6-formyl-5,7-dihydroxy derivative depending on the reaction condition. Cyclization of both leads to the corresponding 3-acetyl-, 3-benzoyl-, 3-carboxamido-, 3-carbethoxybenzodipyran derivatives. The 3-acetylbenzodipyran derivative when treated with ethyl acetoacetate or ethyl cyanoacetate...