The ideal choices for the tasks presented in the project proposal would be the NVIDIA CUDA toolkit (http://developer.nvidia.com/object/cuda. html), which exposes more underlying architecture to programmers. However, the package requires a capable NVIDIA video card, and we could not get for this project. ATI also designed a similar platform “Close-to-Metal (CTM) Device” (http://ati.de/companyinf...

DNA, the hereditary material of the cell, is folded into protein-containing fibers in the nucleus of eukaryotes. The structure and location of these fibers is thought to be important in determining whether molecular machines can access the DNA for important cellular processes such as gene activation. Introduction Each human cell nucleus contains approximately 6 billion base pairs (bp) of deoxyr...

Semantic knowledge refers to the information that people have about categories of objects and living things. Social psychologists have long debated whether the information that perceivers have about categories of people i.e. stereotypes may be a unique form of semantics. Here, we examine this question against well-established findings regarding the neural basis of semantics, which suggest that ...

It has been shown for the first time that relatively electron deficient triazolium pre-catalysts promote (at low loadings in the presence of base) highly chemoselective crossed acyloin condensation reactions between aldehydes and a-ketoesters to afford densely functionalized products incorporating a quaternary stereocentre of considerable synthetic potential. Hydroacylation pathways which have ...

Yoshinao Hara1, Ryusuke Yokoyama1, Keishi Osakabe2, Seiichi Toki3 and Kazuhiko Nishitani1,* Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Sendai, 980-8578, Japan, Center for Collaboration among Agriculture, Industry and Commerce, University of Tokushima, Tokushima, 770-8501 Japan and Plant Genome Engineering Research Unit, National I...

We demonstrate that a pair of perpendicular electrical dipolar scatterers resonating at different frequencies can be used as a metamaterial unit cell to construct a nanometer-thin retarder in reflection, designing nanocross and nanobrick plasmonic configurations to function as reflecting quarter-wave plates at ~1520 and 770 nm, respectively. The design is corroborated experimentally with a mono...

The pharmacokinetics (PK) of biologic therapeutics, especially monoclonal antibodies (mAbs), in monkeys generally presents the most relevant predictive PK information for humans. However, human mAbs, xenogeneic proteins to monkeys, are likely to be immunogenic. Monkeys previously treated with a human mAb (nonnaïve) may have developed antidrug antibodies (ADAs) that crossreact with another test ...