Brandeis University, Waltham, MA 02454 9 10 11 12 13 14 15 Running title: Activity regulates PSD-95-mediated synaptic strengthening 16 17 Correspondence: John E. Lisman 18 Biology Department and Volen Center for Complex Systems 19 Brandeis University, Waltham, MA 02454 20 E-mail: [email protected] 21 Phone: 781-736-3145 22 Fax: 781-736-3107 23 24 25 Articles in PresS. J Neurophysiol (November...

KP-736, a new cephen antibiotic with a broad antibacterial spectrum and potent antipseudomonal activity, was evaluated for in vitro antibacterial activity in comparison with ceftazidime, cefotaxime, and cefpirome. KP-736 was significantly more active than the test compounds against gram-negative bacteria, including the Pseudomonas group and ceftazidime-, cefotaxime-, or imipenem-resistant strai...

The iron hormone hepcidin is inhibited by matriptase-2 (MT2), a liver serine protease encoded by the TMPRSS6 gene. Cleaving the bone morphogenetic protein (BMP) coreceptor hemojuvelin (HJV), MT2 impairs the BMP/son of mothers against decapentaplegic homologs (SMAD) signaling pathway, down-regulates hepcidin, and facilitates iron absorption. TMPRSS6 inactivation causes iron-deficiency anemia ref...

A series of V1?x-Fe-Co-Ni-Al1+x and V1?x-Fe-Co-Ni-Cu1+x high entropy alloys with varying compositions (0 ? x 0.75) has been investigated for magnetocaloric applications. Compositions were selected according to established properties, such as configurational entropy, atomic size difference, enthalpy mixing. To study the influence composition on magnetic ordering temperatures, V (Al/Cu) contents ...

Sapogenins are relatively cheap raw materials for the synthesis of a number of medicinally important steroids. Diosgenin is an aglycone of the steroidal saponin, dioscin, in yam and is a principal raw material for the industrial production of steroid drugs. It belongs to triterpene group and is of great interest to the pharmaceutical industry because of its estrogenic effect on the mammary glan...

J Am Med Inform Assoc. 2008;15:729 –736. DOI 10.1197/jamia.M2547. ccess ss in or nts ts able. port si-