The RAS/RAF/MEK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) pathway is one of the main signaling systems that manage proliferation, differentiation and cell survival, as well as cell cycle and apoptosis. In this pathway, a cascade of phosphorylation events affects three key kinases: RAF, MEK (MAPK kinase) and ERK (MAP kinase). While MEK is not frequently mutat...

, 733 (2011); 333 Science et al. Jacob S. Kanady Complex in Photosystem II Ca Subsite of the Oxygen-Evolving 3 A Synthetic Model of the Mn This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Perm...

We investigate error orders for integral limit approximations to traces of products Toeplitz matrices generated by integrable functions on [ − π , ] having some singularities at the origin. Even though a sharp order above approximation is derived in Theorem 2 Lieberman and Phillips (2004, Journal Time Series Analysis, 25(5) 733–753), its proof contains an inaccuracy. In present article, we rein...

Introduction: Dhofar 733 is a 98-g lunar meteorite collected in the Dhofar region of Oman in 2002 [1]. In the initial description [1], Dhofar 733 is described as an anorthositic granulitic breccia, one that is probably not paired with any other lunar meteorite on the basis of its unique texture and isolation from other lunar meteorites (the next closest lunar meteorite was found 22 km away). Th...

1 Academic Unit of Health Economics and NICE Decision Support Unit, Leeds Institute of Health Sciences, University of Leeds, Leeds, UK 2 Centre for Health Economics, Department of Economics and NICE Decision Support Unit, University of York, Heslington, York, UK 3 Centre for Health Economics, Department of Economics, University of York, Heslington, York, UK 4 Department of Health Policy Managem...

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Introduction: the scope of this article 704 Dienert’s work on adaptation of yeast to galactose 707 Enzymic adaptation or selection of mutants? 709 Galactose fermentation by yeasts 713 Monod’s work on lactose utilization by Escherichia coli 714 Gratuitous induction 716 ‘Permeases’: transport of metabolites into the cells 718 Carbon catabolite repression 720 The operon 722 The galactose pathway i...

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