T-705 (Favipiravir) is a broad-spectrum antiviral molecule currently in late stage clinical development for the treatment of influenza virus infection. Although it is believed that T-705 potency is mediated by its ribofuranosyl triphosphate (T-705 RTP) metabolite that could be mutagenic, the exact molecular interaction with the polymerase of influenza A virus (IAVpol) has not been elucidated. H...

Experimental Biology and Medicine Antonis Kirmizis and Peggy J. Farnham Genes Genomic Approaches That Aid in the Identification of Transcription Factor Target 2004, 229:705-721. Experimental Biology and Medicine http://ebm.rsmjournals.com/content/229/8/705 Updated information and services can be found at: http://ebm.rsmjournals.com/content/229/8/705#BIBL This article cites 117 articles, 57 of w...

The prevalence of sarcocystosis in cattle and water buffaloes from peninsular Malaysia was investigated in abattoirs in Selangor state, February, 2011, to March, 2012. Fresh muscle samples were collected from the tongue, heart, oesophagus, diaphragm and skeletal muscles of 102 cattle and 18 water buffaloes. Each sample was initially screened by light microscopy and then fixed for further histop...

Favipiravir (T-705 [6-fluoro-3-hydroxy-2-pyrazinecarboxamide]) and oseltamivir were combined to treat influenza virus A/NWS/33 (H1N1), A/Victoria/3/75 (H3N2), and A/Duck/MN/1525/81 (H5N1) infections. T-705 alone inhibited viruses in cell culture at 1.4 to 4.3 microM. Oseltamivir inhibited these three viruses in cells at 3.7, 0.02, and 0.16 microM and in neuraminidase assays at 0.94, 0.46, and 2...

Several novel anti-influenza compounds are in various phases of clinical development. One of these, T-705 (favipiravir), has a mechanism of action that is not fully understood but is suggested to target influenza virus RNA-dependent RNA polymerase. We investigated the mechanism of T-705 activity against influenza A (H1N1) viruses by applying selective drug pressure over multiple sequential pass...

A number of New World arenaviruses (Junín [JUNV], Machupo [MACV], and Guanarito [GTOV] viruses) can cause human disease ranging from mild febrile illness to a severe and often fatal hemorrhagic fever syndrome. These highly pathogenic viruses and the Old World Lassa fever virus pose a significant threat to public health and national security. The only licensed antiviral agent with activity again...

Laryngeal papillomas are caused by infection of the laryngeal epithelium by human papillomavirus type 6 or type 11 (HPV-6/-11). Previous studies in our laboratory have demonstrated an increase in PI3 kinase levels in papilloma tissue. However, activation of the downstream effector of PI3 kinase, protein kinase B (PKB/Akt), was reduced. This observation was explained by the elevated expression o...

1. LoRusso FJ, Boniuk M, Font RL. Melanocytoma (magnocellular nevus) of the ciliary body: report of 10 cases and review of the literature. Ophthalmology. 2000;107:795-800. 2. McCartney ACE. Intraocular epithelial tumors and cysts. In: Garner A, Klintworth GK, eds. Pathobiology of Ocular Disease: A Dynamic Approach. 2nd ed, part B. New York, NY: Marcel Dekker; 1994:1405-1421. 3. Shields JA, Shie...

BACKGROUND Inhibition of cholesteryl ester transfer protein (CETP) is an efficient way to increase high-density lipoprotein (HDL) levels in humans. We investigated the effects of the inhibition of CETP activity by a CETP inhibitor, JTT-705, on the function and composition of HDL particles. METHODS AND RESULTS Japanese white rabbits were fed either normal rabbit chow LRC-4 (n=10) or a food adm...

Received: February 9, 2011 • Revised: February 12, 2011 • Accepted: February 15, 2011 Corresponding Author: Ducksun Ahn Department of Plastic and Reconstructive Surgery, Korea University Medical College, 126-1 Anam-dong 5-ga, Seongbuk-gu,, Seoul 136-705, Korea Tel: +82.2.920.5342 Fax: +82.2.920.6198 email: [email protected] Korean J Med Educ 2011 Jun; 23(2): 79-81. doi: 10.3946/kjme.2011.23.2.7...