Prostate cancer is one of the four most common cancers in the U.S., affecting one of six men. Increased serum levels of androgens and IGF-I are associated with an augmented risk of prostate cancer. Dihydrotestosterone (DHT) and testosterone (T) stimulate prostate cancer cell growth, development, and function, whereas the effects of DHT and T in prostate stromal cells, and of DHEA in prostate ca...

Prostate cancer is one of the four most common cancers in the United States, affecting one of six men. Increased serum levels of androgens and IGF-I are associated with an augmented risk of prostate cancer. Dihydrotestosterone (DHT) and testosterone (T) stimulate prostate cancer cell growth, development, and function, whereas the effects of DHT and T in prostate stromal cells, and of dehydroepi...

We recently reported that castration exacerbates albuminuria, glomerulosclerosis, and tubulointerstitial fibrosis associated with diabetic renal disease. The aim of the present study was to examine whether these effects of castration can be attenuated with dihydrotestosterone (DHT) supplementation. The study was performed in castrated male Sprague-Dawley, streptozotocin-induced diabetic rats tr...

Abstract Introduction Although Hypoactive Sexual Desire Disorder (HSDD) is a common condition with relevant impact on women’s quality of life, approved androgenic formulations for its treatment are lacking. In previous studies, we demonstrated that the administration Dihydrotestosterone (DHT), non-aromatizable androgen, in ovariectomized (OVX) Long-Evans rats primed Estradiol Benzoate (EB), enh...

Fast algorithms for computing the DHT of short transform lengths (N = 2, 3, 4, 5, 7, 8, 9 and 16) are derived. A new prime-factor algorithm is also proposed to compute the long-length DHTs from the short-length DHT algorithms. The short-length algorithms (except for N = 8 and N = 16) are such that the even and the odd parts of the DHT components are obtained directly, without any additional com...

(60-79 years and 80-89 years) men, the mean•}SEM for serum DHT were 98•}12, 91•}9, 82•}7 and 54•}15 (ng/100 ml), respectively. The corresponding values for T were 696•}27, 698•}18, 624•}20 and 457•}21 (ng/100ml). DHT and T showed significant correlation in each age group: r=0.625, p <0.05 (young men), r=0.727, p<0.02 (middle aged men), r=0.673, p <0.05 and r=0.734, p <0.02 (old men), respective...

Studies indicate that, whereas immune functions in males are depressed, they are enhanced in females after trauma hemorrhage. Moreover, castration of male mice (i.e., androgen depletion) before trauma hemorrhage prevented the depression of cell-mediated immunity. Nonetheless, it remains unknown whether or not testosterone per se is responsible for producing the immune depression. To study this,...

The possibility that dihydrotestosterone (DHT) may be the intracellular active form of testosterone (Bruchovsky & Wilson, 1968) has led to many investigations of their effects on reproductive structures in both sexes (Gloyna & Wilson, 1969; Gonzalez-Diddi, Komisaruk & Beyer, 1972). In this communication, the synergistic effects of testosterone propionate (TP) and DHT on oestradiol stimulation o...

We have established organ cultures of human prostate for in vitro analysis of the hormone responsiveness of prostatic carcinoma. Tissue samples were obtained from total prostatectomies for localized cancer. Normal prostate tissues with age-related hyperplastic changes were obtained from cystoprostatectomies of bladder cancer patients representing the same age group, and they wer cultivated as c...

Static DHT topologies influence important features of such DHTs such as scalability, communication load balancing, routing efficiency and fault tolerance. Nevertheless, it is commonly recognized that the primary difficulty in designing DHT is not in static DHT topologies, but in the dynamic DHT algorithm which adapts various static DHT topologies to a dynamic network at Internet. As a direct co...