To understand a complex reaction, it is necessary to project the dynamics of the system onto a low-dimensional subspace of physically meaningful coordinates. We recently introduced an automatic method for identifying coordinates that relate closely to stable-state commitment probabilities and successfully applied it to a model for biomolecular isomerization, the C(7eq)-->alpha(R) transition of ...

A 140-kDa polypeptide (p140) has been purified over 2000-fold from vegetative Schizosaccharomyces pombe cells using an assay of homologous pairing and strand exchange between linear double-stranded DNA (dsDNA) and circular single-stranded DNA (ssDNA) in vitro. Electron microscopic analysis of the reaction products showed displacement of one strand of the linear duplex DNA by the circular ssDNA ...

This paper analyzes the scope for systematic rules-based fiscal activism in open economies. Relative to a balanced budget rule, automatic stabilizers significantly improve welfare. But they minimize fiscal instrument volatility rather than business cycle volatility. A more aggressively countercyclical tax revenue gap rule increases welfare gains by around 50 percent, with only modest increases ...

Moda, zamana ve mekana göre değişen, karmaşık bir yapısı bulunan olgudur. Moda olgusunun gelişiminde giysi biçimlerindeki yenilikler önemli rol oynamıştır. Farklı giyim tarzına sahip olma daha çok beğenilme düşüncesi moda akımlarının ortaya çıkmasına zemin hazırlamıştır. Bu nedenle, sektöründe marka imajının önemi giderek artmıştır. Tüketiciler de markasını tercih ederken imajından fazla etkile...

BACKGROUND Contemporary outcomes of percutaneous transluminal angioplasty for the treatment of infrapopliteal atherosclerotic lesions are not well characterized. Hence, a systematic review and meta-analysis was performed to determine the safety and effectiveness of this approach in patients with advanced below-the-knee arterial disease. METHODS AND RESULTS MEDLINE and EMBASE databases were se...

Introduction Little is known about the pattern and outcome of Acute Kidney injury (AKI) in Sudan. This study aimed to determine the etiology and outcome of AKI among Sudanese adults. Methods A retrospective cohort study was conducted in a tertiary level hospital, Soba University Hospital, Sudan. The medical records of all adults admitted to hospital from the 1st of January to 31st of December...

PURPOSE This prospective study examined how environmental smoking affects the perception of lifetime smoking prevalence and thereby the likelihood of subsequent regular smoking. METHODS A longitudinal design (N = 6769) with three waves was used to test our research questions. Exposure to smoking by peers, best friends, and parents were assessed at T1. Perception of lifetime smoking prevalence...

7 1. Department of Pathology, New York University School of Medicine, New York, NY, United 8 States 9 2. Department of Immunology and Applied Biotechnology, University of Rome “Tor Vergata”, 10 Rome, Italy 11 3. “Chantal Biya” International Reference Center, Sequencing Unit, Yaounde, Cameroon 12 4. Faculty of Sciences, University of Dschang, Dschang, Cameroon 13 5. Serology Unit, Medical Diagno...

Received 10/28/2003; revised 12/6/2003; accepted 12/28/2003. For correspondence or reprints contact: Ching-Yee Oliver Wong, M.D., Ph.D., Positron Diagnostic Center, Department of Nuclear Medicine, William Beaumont Hospital, 3601 W., Thirteen Mile Road, Royal Oak, Michigan 48073-6769, USA. Tel: (248)-5514132, Fax: (248)-5517344, E-mail: [email protected] Lung cancer is responsible for 32% of al...