نتایج جستجو برای: 642 and 496
تعداد نتایج: 16827814 فیلتر نتایج به سال:
Increased concentrations of DNA-containing immune complexes in the serum are associated with systemic autoimmune diseases such as lupus. Stimulation of Toll-like receptor 9 (TLR9) by DNA is important in the activation of plasmacytoid dendritic cells and B cells. Here we show that HMGB1, a nuclear DNA-binding protein released from necrotic cells, was an essential component of DNA-containing immu...
Invadopodiaandpodosomes, collectively referred toas invadosomes, are F-actin-rich basal protrusions of cells that provide sites of attachment to and degradation of the extracellular matrix. Invadosomes promote the invasion of cells, ranging from metastatic cancer cells to immune cells, into tissue. Here, we show that neuronal growth cones form protrusions that share molecular, structural and fu...
Pete Seiler Mechanical Eng. Dept. U. of California-Berkeley Berkeley, CA 94720-1740, USA Phone: 1-510-642-6933 Fax: 1-510-642-6163 [email protected] Bong-Sob Song Mechanical Eng. Dept. U. of California-Berkeley Berkeley, CA 94720-1740, USA Phone: 1-510-642-6933 Fax: 1-510-642-6163 [email protected] J. Karl Hedrick Mechanical Eng. Dept. U. of California-Berkeley Berkeley,...
Study Tips Hints to help you review more effectively. Answer Sheets Write the letter of the correct answer for the questions in the review tests. Although only one set of answer sheets are included, you can take these tests as often as you want. Review Session A 100-multiple-choice question Review Session to help you determine where you need more study emphasis. However, be aware that none of t...
Synopsis The conquest of land has endowed air-breathers with the capability to utilize ventilation not only to acquire oxygen but also to control blood and intracellular acid-base state. Hypercapnic acidosis (resulting from ventilatory control and/or behavioral choice), thus, has become a universal component of hypometabolic states in air-breathers, with inhibitory and/or protective roles. Here...
Methylated DNA binding protein 2 (MBD2) binds methylated promoters and suppresses transcription in cis through recruitment of a chromatin modification repressor complex. We show here a new mechanism of action for MBD2: suppression of gene expression indirectly through activation of microRNA hsa-mir-496. Overexpression of MBD2 in breast epithelial cell line MCF-10A results in induced expression ...
BACKGROUND A dry powder inhaler of KP-496 is currently in clinical development in Japan as an anti-asthmatic agent. The aim of this study was to evaluate the in vitro pharmacological profile of KP-496. METHODS The antagonistic activities of KP-496 for leukotriene (LT) D(4) and thromboxane (TX) A(2) receptors were examined using the LTD(4)- and U46619-induced contractions of the isolated guine...
We present preliminary results of imaging and spectral analysis of the cluster A496 with the S3 chip on-board the Chandra satellite. We confirm the presence of a cooling flow and radial gradients in elemental abundances. The cluster’s core has clear signs of substructures (sharp edges, cavities), similar to those recently found in other cooling flow clusters. The O/Fe ratio distribution indicat...
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