Organic anion–transporting polypeptide 1B1 (OATP1B1) is an important hepatic uptake transporter, of which the polymorphic variant OATP1B1*15 (Asn130Asp and Val174Ala) has been associated with decreased transport activity. Rosuvastatin is an OATP1B1 substrate and often concomitantly prescribed with oral antidiabetics in the clinic. The aim of this study was to investigate possible drug-drug inte...

The present study was performed to characterize the disposition and a1-adrenoceptor binding of JTH-601, a novel a1L-adrenoceptor antagonist, and its metabolites (b-D-glucopyranosyl uronic acid, JTH-601-G1; hydrogen sulfate, JTH-601-S1) in the rat prostate and other tissues. JTH-601, JTH-601-G1, and JTH-601-S1 inhibited competitively specific [H]tamsulosin binding in the prostate, submaxillary g...

The PowerPC 601” microprocessor (601) is the first member of a family of processors that support IBM’s PowerPC Architecture”. The 601 Is a general-purpose processor based on a superscalar design point. As with any development effort, the 601 development program had several different, often conflicting, design goals. The most important requirements were support for the PowerPC Architecture, a sh...

131I-TM-601 is a 36-amino acid peptide, called chlorotoxin (TM-601), derived from scorpion venom labeled with I-131. TM-601 binds a receptor on the surface of tumor cells, and not on normal cells. A single dose of 131I-TM-601 administered intracranially to human xenografted mouse models of glioma has been shown to extend survival up to 269% in multiple studies. 131I-TM-601 is in a multi-center ...

131I-TM-601 is a 36-amino acid peptide, called chlorotoxin (TM-601), derived from scorpion venom labeled with I-131. TM-601 binds a receptor on the surface of tumor cells, and not on normal cells. A single dose of 131I-TM-601 administered intracranially to human xenografted mouse models of glioma has been shown to extend survival up to 269% in multiple studies. 131I-TM-601 is in a multi-center ...

Notes on Paper #1 for week 8 of CPSC601.47 Tabletop and Interactive Surfaces. Prepared by Erika Harrison Discussed Paper: Mark Hancock, Sheelagh Carpendale and Andy Cockburn. Shallow-Depth 3D Interaction: Design and Evaluation of One-, Twoand Three-Touch Techniques. In CHI ’07: Proceedings of the SIGCHI conference on Human factors in computing systems. (New York, NY, USA), ACM Press, pp 1147-11...

We compared the potency of SMP-601, a novel carbapenem, with that of vancomycin in a murine model of hematogenous bronchopneumonia infection caused by methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-intermediate S. aureus (VISA). The MICs of SMP-601 and vancomycin against MRSA were 2 and 1 mug/ml, respectively, while those against VISA were 2 and 8 mug/ml, respectively. Treatm...

In this problem we illustrate how gradients can be used to solve the least squares problem. Suppose we have input data matrix X ∈ Rn×p, output data y ∈ R and weight vector w ∈ R, where p is the number of features per observation. The linear system Xw = y corresponds to choosing a weight vector w that perfectly predicts yi given X{i, :} for all observations i = 1, . . . , n. The least squares pr...

To produce a marketable PowerPC" microprocessor on a short development schedule, the logic had to be designed in a manner flexible enough to allow quick modifications without sacrificing high performance and density when customized cells were required. This was accomplished for the PowerPC 601'" microprocessor (601) with a high-level design-language description, which was synthesized for a gate...