نتایج جستجو برای: 5p deletion

تعداد نتایج: 88488  

2017
Deepak Arya Sasikala P Sachithanandan Cecil Ross Dasaradhi Palakodeti Shang Li Sudhir Krishna

The deregulation of lineage control programs is often associated with the progression of haematological malignancies. The molecular regulators of lineage choices in the context of tyrosine kinase inhibitor (TKI) resistance remain poorly understood in chronic myeloid leukemia (CML). To find a potential molecular regulator contributing to lineage distribution and TKI resistance, we undertook an R...

2017
Man Teng Zu-Hua Yu Pu Zhao Guo-Qing Zhuang Zi-Xiang Wu Lu Dang Hui-Zhen Li Sheng-Ming Ma Zhi-Zhong Cui Gai-Ping Zhang Run Wu Jun Luo

In the last decade, numerous microRNAs (miRNAs) have been identified in diverse virus families, particularly in herpesviruses. Gallid alphaherpesvirus 2 (GaHV2) is a representative oncogenic alphaherpesvirus that induces rapid-onset T-cell lymphomas in its natural hosts, namely Marek's disease (MD). In the GaHV2 genome there are 26 mature miRNAs derived from 14 precursors assembled into three c...

Journal: :The Journal of clinical investigation 2016
Alexander M K Rothman Nadine D Arnold Josephine A Pickworth James Iremonger Loredana Ciuclan Robert M H Allen Sabine Guth-Gundel Mark Southwood Nicholas W Morrell Matthew Thomas Sheila E Francis David J Rowlands Allan Lawrie

Loss of the growth-suppressive effects of bone morphogenetic protein (BMP) signaling has been demonstrated to promote pulmonary arterial endothelial cell dysfunction and induce pulmonary arterial smooth muscle cell (PASMC) proliferation, leading to the development of pulmonary arterial hypertension (PAH). MicroRNAs (miRs) mediate higher order regulation of cellular function through coordinated ...

Journal: :Nature communications 2016
Irinna Papangeli Jongmin Kim Inna Maier Saejeong Park Aram Lee Yujung Kang Keiichiro Tanaka Omar F Khan Hyekyung Ju Yoko Kojima Kristy Red-Horse Daniel G Anderson Arndt F Siekmann Hyung J Chun

G protein-coupled receptor (GPCR) signalling, including that involving apelin (APLN) and its receptor APLNR, is known to be important in vascular development. How this ligand-receptor pair regulates the downstream signalling cascades in this context remains poorly understood. Here, we show that mice with Apln, Aplnr or endothelial-specific Aplnr deletion develop profound retinal vascular defect...

Journal: :American Journal of Obstetrics and Gynecology 2022

Non-invasive prenatal screening with cell free DNA (cfDNA) includes the option to screen for microdeletion syndromes but data on test performance are limited. We report of cfDNA detection 4 syndromes: Cri-Du-Chat (5p-), Prader-Willi syndrome (PWS), Angelman (AS) and 1p36del syndrome. Secondary analysis SMART multicenter prospective study, which assessed 22q11.2 deletion. Newborn or fetal sample...

Journal: :Aging Cell 2007
Hong-Yan Du Rachel Idol Sara Robledo Jennifer Ivanovich Ping An Arturo Londono-Vallejo David B Wilson Philip J Mason Monica Bessler

Telomerase, which maintains the ends of chromosomes, consists of two core components, the telomerase reverse transcriptase (TERT) and the telomerase RNA (TERC). Haploinsufficiency for TERC or TERT leads to progressive telomere shortening and autosomal dominant dyskeratosis congenita (DC). The clinical manifestations of autosomal dominant DC are thought to occur when telomeres become critically ...

2016
Andrew D. Gaudet Laura K. Fonken Liubov V. Gushchina Taryn G. Aubrecht Santosh K. Maurya Muthu Periasamy Randy J. Nelson Phillip G. Popovich

Obesity is a growing epidemic in developed countries. Obese individuals are susceptible to comorbidities, including cardiovascular disease and metabolic disorder. Increasing the ability of adipose tissue to expend excess energy could improve protection from obesity. One promising target is microRNA (miR)-155-5p. We demonstrate that deletion of miR-155 (-5p and -3p) in female mice prevents diet-...

Journal: :Journal of medical genetics 1999
K M Cornish G Cross A Green L Willatt J M Bradshaw

Cri du chat syndrome is associated with a deletion on the short arm of chromosome 5. The main diagnostic feature is a high pitched, cat-like cry which has recently been localised to 5p15.3 and is separate from the remaining clinical features of the syndrome, which have been localised to 5p15.2. The present study describes a family of four who have a deletion slightly distal (5p15.3) to the crit...

2016
Ashok Singh Estelle Willems Anupama Singh Bilal Bin Hafeez Irene M. Ong Suresh L. Mehta Ajit Kumar Verma

Chronic exposure to ultraviolet radiation (UVR) is linked to the development of cutaneous squamous cell carcinoma (SCC), a non-melanoma form of skin cancer that can metastasize. Tumor necrosis factor-alpha (TNFα), a pro-inflammatory cytokine, is linked to UVR-induced development of SCC. To find clues about the mechanisms by which TNFα may promote UVR-induced development of SCC, we investigated ...

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