The serotonin transporter (5HTT) may be associated with the pathogenesis of major depressive disorder (MDD). The 5HTT-linked polymorphic region (5HTTLPR) genotype may determine how levels of 5HTT mRNA are influenced by promoter methylation. We examined the association of 5HTT gene methylation, which influences gene expression, and the 5HTTLPR genotype before antidepressant treatment and express...

BACKGROUND Cross-sectional studies suggest that the serotonin transporter promoter region polymorphism (5-HTT gene-linked polymorphic region, 5HTTLPR) moderates the relationship between childhood abuse and major depressive disorder. AIMS To examine whether the 5HTTLPR polymorphism moderates the effect childhood abuse has on 5-year depressive symptom severity trajectories in adulthood. METHO...

CONTEXT Efforts to classify eating-disordered individuals based on concurrent personality traits have consistently converged on a typology encompassing "over-regulated", "dysregulated", and "low psychopathology" subgroups. In various populations, evidence has associated personality variations of an "over-regulated/dysregulated" type with differences on serotonin-system indices, and specifically...

A significant amount of research has examined the interaction between a functional polymorphism in the serotonin transporter gene (5HTTLPR) and stressful life events in the prediction of depression and depressive symptomatology. The results of these studies have produced conflicting evidence, with some studies substantiating a significant interaction and others failing to detect a significant i...

Background: An epidemiological study in the USA recently reported that variations in the serotonin transporter gene-linked polymorphic region (5HTTLPR) can influence subjective well-being or happiness; specifically, individuals with long polymorphisms (L-allele carriers), associated with increased serotonin reuptake activity, reported significantly higher levels of life satisfaction compared to...

Alzheimer's disease (AD) is a progressive neurodegenerative disease. Relationships of 5HT2A and 5HTTLPR polymorphisms and AD risk have been widely investigated previously, whereas results derived from these studies were inconclusive and controversial. The aim of this study was to investigate the association of the 5-HT2A and 5HTTLPR polymorphisms and AD using a meta-analysis of existing literat...

Individual differences in cognitive function are highly heritable and most likely driven by multiple genes of small effect. Well-characterized common functional polymorphisms in the genes MAOA, COMT, and 5HTTLPR each have predictable effects on the availability of the monoamine neurotransmitters dopamine, noradrenaline, and serotonin. We hypothesized that 5HTTLPR genotype would show little asso...

The purpose of this study was to determine the relationship between personality, the serotonin transporter (5HTT) polymorphisms and the occurrence of anxiety and depressive symptoms in elite athletes. 133 healthy participants completed the NEO Five-Factor Inventory (NEO-FFI). The mood states were assessed using the Profile of Mood States (POMS) questionnaire. The athlete's mental skills were as...

BACKGROUND The 5HTTLPR genetic variant of the serotonin transporter gene (SERT or 5-HTT), which is comprised of a short (SERT-s) and a long (SERT-l) allele, is associated with major depressive disorder and post-traumatic brain disorder. AIMS The present study sought to determine whether the total thalamus and major subregions are altered in size in major depressive disorder and in relation to...

Background: Despite its effectiveness, there are still many concerns and questions about the principles and therapeutic methods of traditional medicine (TM). In other words, in order to accept TM as a reliable health care system, its proficiency need to be declared through modern scientific research. One of the major determinants of Persian medicine (PM) which is practically utilized in disease...