of the Dissertation Medical Embedded Systems

A key event in the process of spermiogenesis is the formation of the flagella, which enables sperm to reach eggs for fertilization. Yeast two-hybrid studies revealed that meiosis-expressed gene 1 (MEIG1) and Parkin co-regulated gene (PACRG) interact, and that spermassociated antigen 16, which encodes an axoneme central apparatus protein, is also a binding partner of MEIG1. In spermatocytes of w...

Defects in the human ferrochelatase gene lead to the hereditary disorder of erythropoietic protoporphyria. The clinical expression of this autosomal dominant disorder requires an allelic combination of a disabled mutant allele and a low-expressed nonmutant allele. Unlike most other erythropoietic protoporphyria populations, mutations identified among Swiss erythropoietic protoporphyria families...

Vahid Shaygannejad, Khodayar Golabchi, Alireza Dehghani, Fereshteh Ashtari, Sepehr Haghighi, Mahsa Mirzendehdel2, Majid Ghasemi1 Department of Neurology, Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Student of Medicine, Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Department of Ophtalmology, Isfahan ...

Recently, many new chaotic flows have been discovered that are not associated with a saddle point, including ones without any equilibrium points, with only stable equilibria, or with a line containing infinitely many equilibrium points [Jafari & Sprott, 2013, 2015; Jafari et al., 2013; Jafari et al., 2015b; Kingni et al., 2014; Lao et al., 2014; Molaie et al., 2013; Pham et al., 2014a; Pham et ...

4-Aminobiphenyl (ABP), a prototypical aromatic amine carcinogen in rodents and humans, requires bioactivation to manifest its toxic effects. A traditional model of ABP bioactivation, based on in vitro enzyme kinetic evidence, had postulated initial N-hydroxylation by the cytochrome P450 isoform CYP1A2. This is followed by phase 2 O-conjugation and hydrolysis to form a reactive nitrenium ion tha...

The extent of the burnt zone has been established by drilling. The thickest section, about 75 metres deep, underlies the Dry Lake gulch near the base of the coal measures. Other profiles of the bllrnt zone give an average thickness of about 25 metres, although thinning and some discontinuity is appartlnt. The present area of the burnt zone amounting to about 3.5 square kilometres is evidently o...

Guillaume Lettre1,2, Anne U Jackson3,25, Christian Gieger4,5,25, Fredrick R Schumacher6,7,25, Sonja I Berndt8,25, Serena Sanna3,9,25, Susana Eyheramendy4,5, Benjamin F Voight1,10, Johannah L Butler2, Candace Guiducci1, Thomas Illig4, Rachel Hackett1, Iris M Heid4,5, Kevin B Jacobs11, Valeriya Lyssenko12, Manuela Uda9, The Diabetes Genetics Initiative24, FUSION24, KORA24, The Prostate, Lung Colo...

* Department of Biology, University of California at San Diego, La Jolla, California 92093-0357, USA § Mikoshiba Calciosignal Net Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Corporation (JST), Tokyo 113-0021, Japan 2 These authors contributed equally to this work. 3 Present address: Department of Biochemistry, New York University School of Medicin...