Osteosarcoma (OS) is the most common primary bone tumor, occurring frequently in adolescents and possessing a high malignant severity. MicroRNAs play critical roles during OS development. Thus, elucidation of the involvement of specific microRNAs in the development of OS may provide novel therapeutic targets for OS treatment. Here, we showed that in the OS specimens from patients, the levels of...

Replacement of cysteine at position 543 by tyrosine in the influenza virus hemagglutinin (HA) protein enables the endocytosis of the mutant protein (Tyr 543) through coated pits (Lazarovits, J., and M. G. Roth. 1988. Cell. 53:743-752). To investigate the interactions between Tyr 543 and the clathrin coats in the plasma membrane of live cells, we performed fluorescence photobleaching recovery me...

The aim of this study was to report a case that underwent a craniotomy after primary pre-operative cerebrovascular and 3D digital subtraction angiography (DSA) showed false results. DSA misdiagnosis and missed diagnosis of aneurysms were found, and the subject was subsequently treated accordingly. This case was analysed to identify: 1) the cause of the false positive and false negative results ...

INTRODUCTION................................................................ 542 TETRACYCLINE PROPHYLAXIS................... 543 Simian Tularemia.................. 543 Human Tularemia................... 544 TETRACYCLINE THERAPY................... 545 OTHER ANTIBIOTICS................... 546 SUMMARY.................................................................... 547 LITERATURE CITED............

OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 543 STRUCTURE OF GENERAL FACTORIAL DESIGNS . . . . . . . . . . . 543 SUITABLE CONFOUNDING RULES . . . . . . . . . . . . . . . . . . . . . 544 Design Factors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 544 Block Factors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 545 Gener...

BACKGROUND/AIMS Elucidation of the molecular mechanisms underlying ovarian cancer (OC) cell invasion and migration may provide important evidence for developing efficient therapy. Recently, Matrix metalloproteinase (MMP) has been shown to be regulated by vascular endothelial growth factor family members, especially placental growth factor (PLGF), as a potential mechanism underlying cancer invas...

Chronic myeloid leukemia (CML) is characterized by a constitutive activation of Bcr-Abl tyrosine kinase. Bcr-Abl/T315I is the predominant mutation that causes resistance to Imatinib. In the present study, we synthesized a novel Bcr-Abl inhibitor, HS-543, and investigated its effect on cell survival or apoptosis in CML cells bearing Bcr-Abl/T315I (BaF3/T315I) or wild-type Bcr-Abl (BaF3/WT). HS-5...

Abstract Introduction Racial and gender disparities have been longstanding in the fields of medicine surgery. In literature, underrepresentation has highlighted plastic surgery general programs, however few studies examine this within burn Two describe racial that exist leadership. This study seeks to compare highlight representation minority female surgeons training at a major metropolitan cen...

The present work deals with the comparison of in vitro dissolution profiles of fenofibrate liquisolid tablet formulations with those of marketed fenofibrate tablets, and the application of statistical methods to evaluate each method for its usefulness. The methods used to study dissolution profile comparison include Model independent method (Similarity factor, f2); Model dependent methods (Zero...