Anemia as associated with numerous clinical conditions can be debilitating, but frequently can be treated via administration of epoetin-alfa, darbepoietin-alfa, or methoxy-PEG epoetin-beta. Despite the complexity of EPO-EPO receptor interactions, the development of interesting EPO mimetic peptides (EMPs) also has been possible. CNTO 530 is one such novel MIMETIBODY Fc-domain dimeric EMP fusion ...

Anemia as associated with numerous clinical conditions can be debilitating, but frequently can be treated via administration of epoetin-alfa, darbepoietin-alfa or methoxy-PEG epoetin-beta. Despite the complexity of EPO-EPO receptor interactions, the development of interesting EPO mimetic peptides (EMPs) also has been possible. CNTO 530 is one such novel MIMETIBODY TM Fc-domain dimeric EMP fusio...

CNTO 530 is an erythropoietin receptor agonist MIMETIBODYTM construct. CNTO 530 has been shown to be active in a number of rodent models of acquired anemia (e.g. renal insufficiency and chemotherapy induced anemia). We investigated the efficacy of CNTO 530 in murine models of β-thalassemia and sickle cell anemia (Berkeley mice). β- thalassemic mice are deficient in expression of α-globin chain ...

To whom correspondence should be addressed: Keesook Lee, Ph.D., Hormone Research Center, Chonnam National University, Gwangju, 500-757, Republic of Korea. Phone: +82-62-530-0509; Fax: +82-62-530-0500; E mail: [email protected]. Won-Jea Cho, Ph.D., College of Pharmacy, Chonnam National University, Gwangju 500-757, Republic of Korea. Phone: +82-62-530-2933; Fax: +82-62-530-2911; E mail: wjcho@ch...

Journal of Comparative NeurologyVolume 530, Issue 6 COVER IMAGEFree Access Cover Image, Volume First published: 10 February 2022 https://doi.org/10.1002/cne.25309AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text full-text accessPlease review our Terms and Conditions Use check box below share version article.I have read accept the...

1 University of California, Davis. Department of Biomedical Engineering. Genome and Biomedical Sciences Facility, 451 E. Health Sciences Dr., Davis, California, 95616-5294. 530-752-1430 (U. S., A. F. H. L., M. R. S.) 530-754-2193 (C. E. G.), 530-752-0299 (S. I. S.). Fax 530-754-5739 2 ICOS Corporation, 22021 20 Ave. SE, Bothell, Washington 98021. 3 Current Address: The Scripps Research Institut...

Introduction 528 Method evaluation 528 Sample collection 530 Isolation methods 530 Preenrichment 530 Enrichment 531 Agar plates 531 Methods for bacterial counts 532 Pathogenic bacteria 533 Campylobacter 533 Clostridium perfringens 536 Listeria 536 Salmonella 537 Spoilage microorganisms 538 Mesotrophic bacteria 538 Psychrotrophic bacteria 539 Yeasts and molds 539 Application of molecular techniq...

CNTO 530 and darbepoetin- are long lived erythropoietin receptor agonists (ERAs). Clinically, anemia of chronic disease (ACD) is associated with increased expression of tumor necrosis factor- (TNF-) and mice transgenic for human TNF- develop ACD. The purpose of this investigation was to compare the effects of these agents in a murine model of ACD. Human TNF- expressing (Tg197) mice were ad...