To understand whether prolonged confinement results in reductions in physical activity and adaptation in the musculoskeletal system, six subjects were measured during 520 d isolation in the Mars500 study. We tested the hypothesis that physical activity reduces in prolonged confinement and that this would be associated with decrements of neuromuscular performance. Physical activity, as measured ...

BACKGROUND MicroRNAs (miRNAs), a class of small non-coding RNA molecules, are indicated to play essential roles in spermatogenesis. However, little is known about the expression patterns or function of miRNAs in human testes involved in infertility. METHODS In this study, the miRNA expression profiles of testes of patients with non-obstructive azoospermia (NOA) and normal controls were perfor...

OBJECTIVE This study aimed to perform screening and bioinformatic analysis of microRNA (miRNA) molecules associated with immune clearance in chronic hepatitis B (CHB) patients. METHODS Peripheral blood mononuclear cells (PBMCs) of CHB patients and healthy individuals were collected and detected by microarray. The target genes of differentially expressed miRNA molecules were predicted using th...

MicroRNAs (miRNAs) are short RNA molecules that negatively regulate gene expression primarily by degrading target mRNA or inhibit the translation of protein product. Recently, many reports have shown the altered miRNA expression in various diseases. However, there are no reports on miRNA expression related to periodontitis. Thus, this study aimed to compare the miRNAs differentially expressed i...