objective(s):oct4 is a transcription factor required for pluripotency during early embryogenesis and the maintenance of identity of embryonic stem cells and pluripotent cells. therefore, the effective expression regulation of this gene is highly critical. utr regions are of great significance to gene regulation. in this study, we aimed to investigate the potential regulatory role played by 5´ut...

The aim of the present study was to detect polymorphism in Insulin like growth factor-I (IGF-I) gene of beluga (Huso huso) fish using PCR-SSCP technique and also investigation of its association with growth traits (condition factor, body length and weight). A total of 150 specimens of beluga were randomly selected and DNA was isolated from caudal fin using modified salting out method. Then two ...

Telah dikemukakan bahwa virus corona menjadi penyebab COVID-19.(1) Virus yang dimaksud yaitu SARS-CoV-2, sedangkan COVID-19 kependekan dari disease-19. adalah penyakit disebabkan oleh SARS-CoV2 muncul awal Desember tahun 2019 di Wuhan, China. Sifat tersebut mudah menginfeksi manusia dan menyebar hampir keseluruh penjuru dunia. Oleh karena itu terjadilah wabah (pandemi) COVID-19.
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Protein translation typically begins with the recruitment of the 43S ribosomal complex to the 5' cap of mRNAs by a cap-binding complex. However, some transcripts are translated in a cap-independent manner through poorly understood mechanisms. Here, we show that mRNAs containing N(6)-methyladenosine (m(6)A) in their 5' UTR can be translated in a cap-independent manner. A single 5' UTR m(6)A dire...

uterine infection is one of the reproductive diseases that can have disturbing postpartumuterine health in cattle. therefore, identification of resistant genotypes to uterine infection isimportant. lactoferrin (lf) is one of the major antimicrobial compounds in the normal uterinedischarges of cows. we hypothesized that allelic diversity in lf gene may contribute tosusceptibility or resistance t...

A nonredundant database of 2312 full-length human 5'-untranslated regions (UTRs) was carefully prepared using state-of-the-art experimental and computational technologies. A comprehensive computational analysis of this data was conducted for characterizing the 5' UTR features. Classification and regression tree (CART) analysis was used to classify the data into three distinct classes. Class I c...