Introduction: Vitiligo is a chronic acquired disorder presenting with depigmented macules and patches. The response to treatment is variable as no single therapy produces predictably good results. Needling with topical 5% 5 fluorouracil in vitiligo has been found to be promising, effective and safe modality of treatment. Materials and methods: Three patients with stable vitiligo were on medical...

OBJECTIVE To compare the efficacy, tolerability, and cosmetic outcome of photodynamic therapy (PDT) using topical methyl aminolevulinate with cryotherapy or topical fluorouracil for treatment of squamous cell carcinoma in situ. DESIGN Randomized, placebo-controlled study, with follow-up at 3 and 12 months after last treatment. SETTING Forty outpatient dermatology centers in 11 European coun...

The recent coronavirus disease 2019 (COVID-19) pandemic has created a quandary for the physician in terms of evaluating and treating cutaneous skin cancers, particularly melanomas. At onset pandemic, many planned medical surgical visits cancers were postponed. Physicians patients have had to balance risk exposure severe acute respiratory syndrome 2 (SARS-CoV-2) with that worsening morbidity mor...

Sir, Nail psoriasis affects 20–55% of psoriatic patients. It often represents a significant cause of distress because of the visible lesions and the chronic course of the disease. Treatment options include corticosteroids, vitamin D3 analogues, 5-fluorouracil, urea, anthralin, cyclosporine and radiotherapy (1). Tazarotene is an acetylenic retinoid with documented therapeutic results in skin pso...

Skin tests to various common antigens, dinitrochlorobenzene, and 5-fluorouracil (5-FU) were performed on patients being treated for cutaneous neoplasms with topical 5-FU cream. Eleven of 15 patients tested both before and after therapy converted from skin test negative to positive with respect to 5-FU. This conversion correlated with positive dinitrochlorobenzene skin tests and therapeutic cure...