This is a 57-year-old right-handed male with a history of locally advanced esophageal adenocarcinoma, who presented with confusion and speech changes. Patient received 5-Fluorouracil (5-FU) and cisplatin four days prior to presentation, which was complicated by very poor oral intake on day 2 of therapy. On the day of presentation, he was confused and his speech was slurred. The remainder of the...

     Several modalities of drug administration have been investigated to improve bioavailability and to reduce 5-FU related toxicity. The aim of present study was to evaluate the effect of skimmed milk on the absorption and metabolism of 5-FU in rabbits, mice and dogs. It was further aimed to determine its route related toxicity in rabbits.    Plasma concentration of both 5-FU and its metabolit...

Background: During treatment, many drugs may become cause of cardiac system toxicity, cytotoxic therapy including 5- Fluorouracil (5- FU). It is regarded as antimetabolite which its toxic effects during S phase the cell cycle and got activation by conversion thymidine phosphorylase into fluorodeoxyuridylate (5 fluoro 2'deoxyuridine 5'monophosphate, 5-FdUMP) inhibition thymidylate synthase, ulti...

Background: Cyclophosphamide (CPA) is a drug with wide spectrum of clinical uses. Its effectiveness in the treatment cancer (acute and chronic leukemias, lymphoma, multiple myeloma) non-malignant diseases such as rheumatoid arthritis vasculitis has been well established. Objectives: The present investigation aimed to study effect sub-lethal dose cyclophosphamide, 5-FU combination 5-FU, CPA on h...

5‐fluorouracil (5-FU), a pyrimidine analogue anticarcinogenic agent, is widely used in the solid tumors treatment. Use of 5-FU causes cardiotoxicity. Our aim this study investigations effects Quercetin and Rutin on ECG parameters 5-FU-induced cardiotoxicity rats. In present male Rats were divided randomly to eight group. The control group was given intragastric corn oil for 14 days. rats ig day...