Aguirre, J. I., N. W. Morrell, L. Long, P. Clift, P. D. Upton, J. M. Polak, and M. R. Wilkins. Vascular remodeling and ET-1 expression in rat strains with different responses to chronic hypoxia. Am J Physiol Lung Cell Mol Physiol 278: L981–L987, 2000.—Chronic hypoxia leads to a greater degree of pulmonary hypertension in the WistarKyoto (WKY) rat than in the Fischer 344 (F-344) rat. We question...

Glasser, Stephan W., Michael S. Burhans, Susan K. Eszterhas, Michael D. Bruno, and Thomas R. Korfhagen. Human SP-C gene sequences that confer lung epithelium-specific expression in transgenic mice. Am J Physiol Lung Cell Mol Physiol 278: L933–L945, 2000.—We used transgenic mice to identify cis-active regions of the human pulmonary surfactant protein C (SP-C) gene that impart tissueand cell-spec...

MINGYAO LIU,1,2 LORRAINE TREMBLAY,1,2 STEPHEN D. CASSIVI,1,2 XIAO-HUI BAI,1,2 ERIC MOURGEON,1,2 ANDREW F. PIERRE,1,2 ARTHUR S. SLUTSKY,3,4 MARTIN POST,5–7 AND SHAF KESHAVJEE1,2 1Thoracic Surgery Research Laboratory, Toronto General Hospital, Toronto M5G 2C4; 3Division of Respiratory Medicine, Mount Sinai Hospital, Toronto M5G 1X5; 5Medical Research Council Group in Lung Development and Lung Bio...

Taylor, B. Keith, Tamara D. Stoops, and Allen D. Everett. Protein phosphatase inhibitors arrest cell cycle and reduce branching morphogenesis in fetal rat lung cultures. Am J Physiol Lung Cell Mol Physiol 278: L1062–L1070, 2000.—Protein phosphatase 2A (PP2A) is a key signal transduction intermediate in the regulation of cellular proliferation and differentiation in vitro. However, the role of P...

Removal of the mRNA 5' cap is an important step in the regulation of mRNA stability. mRNAs are degraded by at least two distinct exonucleolytic decay pathways, one from the 5' end, and the second from the 3' end. Two major cellular decapping enzymes have been identified, and each primarily functions in one of the two decay pathways. The Dcp2 decapping enzyme utilizes capped mRNA as substrate an...

Objective: Nearly 25% of IgA nephropathy patients progress to end-stage renal disease over a 20-25 year follow-up period. IgA containing immune complex stimulates oxygen free radical production by mesangial cells in vitro, which may mediate glomerular injury in this disorder. Therefore, we studied whether dietary supplementation with the antioxidant agent, vitamin E, attenuates renal damage in ...

This is sometimes called the Netflix problem. A motivation for the matrix completion problem comes from user ratings of some products which are put into a matrix M . The entries Mij of the matrix correspond to the j’th user’s rating of product i. We assume that there exists an ideal matrix that encodes the ratings of all the products by all the users. However, it is not possible to ask every us...

Obituary
 Joseph Agassi (May 7, 1927 – January 22, 2023)