نتایج جستجو برای: 5 صدرائیان

تعداد نتایج: 1215773  

2012
Chun-Xiao Song Chengqi Yi Chuan He

Nucleotide variants, especially those related to epigenetic functions, provide critical regulatory information beyond simple genomic sequence, and they define cell status in higher organisms. 5-Methylcytosine, which is found in DNA, was until recently the only nucleotide variant studied in terms of epigenetics in eukaryotes. However, 5-methylcytosine has turned out to be just one component of a...

2016
Thuy T M Ngo Jejoong Yoo Qing Dai Qiucen Zhang Chuan He Aleksei Aksimentiev Taekjip Ha

Cytosine can undergo modifications, forming 5-methylcytosine (5-mC) and its oxidized products 5-hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-fC) and 5-carboxylcytosine (5-caC). Despite their importance as epigenetic markers and as central players in cellular processes, it is not well understood how these modifications influence physical properties of DNA and chromatin. Here we report a co...

2016
Hao Lian Wen-Bin Li Wei-Lin Jin

The Ten-eleven translocation (TET) proteins have been recently identified as critical regulators in epigenetic modification, especially in the methylation of cytosine in DNA. TET-mediated DNA oxidation plays prominent roles in a wide variety of physiological and pathological processes, especially in tumor and neural development. TET proteins execute stepwise enzymatic conversion of 5-methylcyto...

2015
Robyn E. Hardisty Fumiko Kawasaki Aleksandr B. Sahakyan Shankar Balasubramanian

We present a chemical method to selectively tag and enrich thymine modifications, 5-formyluracil (5-fU) and 5-hydroxymethyluracil (5-hmU), found naturally in DNA. Inherent reactivity differences have enabled us to tag 5-fU chemoselectively over its C modification counterpart, 5-formylcytosine (5-fC). We rationalized the enhanced reactivity of 5-fU compared to 5-fC via ab initio quantum mechanic...

Journal: :Angewandte Chemie 2015
Mirko Wagner Jessica Steinbacher Theo F J Kraus Stylianos Michalakis Benjamin Hackner Toni Pfaffeneder Arshan Perera Markus Müller Armin Giese Hans A Kretzschmar Thomas Carell

The absolute levels of 5-hydroxymethylcytosine (hmC) and 5-methylcytosine (mC) in human brain tissues at various ages were determined. Additionally, absolute levels of 5-formylcytosine (fC) in adult individuals and cytosine modification levels in sorted neurons were quantified. These data were compared with age-related fC, hmC, and mC levels in mouse brain samples. For hmC, an initial steady in...

آزاد همتی, احمد برجعلی, علی دلاور, محمدکاظم عاطف وحید محمود دژکام کامبیز کامکاری

این پژوهش با هدف کلی مطالعه انطباق ساختار پنج عاملی شخصیت مرضی (PSY-5) با محور دوم DSM-5 در قالب یک پژوهش پیمایشی پرسشنامه­ای انجام گرفته است. پژوهش از جمله مطالعات روش­شناسی و آزمون­سازی به حساب می­آید. در این تحقیق ابتدا حمایت تجربی داده­های ایرانی برای ساختار پنج عاملی شخصیت مرضی (PSY-5) و ساختار عاملی صفات و حیطه­های کلی شخصیت DSM-5 مطالعه شدند. سپس همخوانی بین مقیاس­های شخصیت مرضی (PSY-5) ...

Journal: :Atlas of Genetics and Cytogenetics in Oncology and Haematology 2011

Journal: :Epidemiology and Psychiatric Sciences 2018

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید