The development, growth, and function of the prostate gland depend on androgen stimulation. The primary androgen in prostate is 5α-dihydrotestosterone (DHT) which is synthesized from circulating testosterone (T) through the action of 5α-reductase (5α-R). Although 5α-R occurs as five isozymes, only 5α-R1 and 5α-R2 are physiologically involved in steroidogenesis. The endocrine disruptor bisphenol...

Benign prostatic hyperplasia (BPH), a leading disorder of the elderly male population, is the nonmalignant enlargement of the prostate gland. It involves an increase in cell numbers in both the epithelial and stromal elements within the periurethal transition zone of the prostate (1). BPH prevalence increases with age affecting around 80% by the age of 80 years causing considerable voiding dysf...

Background: Benign prostatic hyperplasia [BPH] is the urologic condition that affects elderly men most frequently hyperplasia. must be distinguished from
 lower urinary tract symptoms and benign enlargement. which refers to an enlarged prostate, a purely histological term development, maintenance, secretory activity of prostate other sex-accessory tissues are stimulated by presence certain...

Avicennia marina (AM) exhibits various biological activities and has been traditionally used in Egypt to cure skin diseases. In this study, the methanolic heartwood extract of AM was evaluated for inhibitory activity against 5α-reductase (5α-R) [E.C.1.3.99.5], the enzyme responsible for the over-production of 5α-dihydrotestosterone (5α-DHT) causing androgenic alopecia (AGA). An AGA-relevant cel...

This article summarizes the importance of different targets such as 5α-reductase, 17β-HSD, CYP17A, androgen receptor and protein kinase A for the treatment of prostate cancer and benign prostatic hyperplasia. It is a well known fact that dihydrotestosterone (DHT) is associated with the development of androgen-dependent afflictions. At the present time, several research groups are attempting to ...

Abstract Introduction According to the Global Consensus Position Statement on Use of Testosterone Therapy for Women, testosterone can significantly improve desire in menopausal women with hypoactive sexual disorder. Based safety and efficacy different formulations, recommended treatment is 1/10th a man’s dose, using government approved topical gel or solution, AndroFeme which use Australia. The...

The androgens testosterone (T) and dihydrotestosterone (DHT), besides playing an important role in prostate development and growth, are also responsible for the development and progression of benign prostate hyperplasia (BPH) and prostate cancer. Therefore, the actions of these hormones can be antagonized by preventing the irreversible conversion of T into DHT by inhibiting 5α-reductase (5α-R)....

The androgen receptor (AR) is known to play critical roles in the malignancy of prostate cancer as well as the management of male reproductive organs. Endometrial carcinoma, one of the major female cancers, is considered an androgen-related cancer. However, the importance of androgen signaling through its receptor in endometrial carcinomas has not yet been clarified. We recently demonstrated th...

OBJECTIVES The present study was aimed to evaluate the time-mannered and dose-dependent effects of 5α-dihydrotestosterone (5α-DHT) on the proliferation and differentiation of bone forming cells using MC3T3-E1 cells. MATERIALS AND METHODS Cell proliferation was analyzed using MTS and phase contrast microscopic assays. Osteogenic differentiation was assessed through a series of in vitro experim...

The disease has four main causes: sebaceous hyperplasia and hyperseborrhoea; hyperkeratinization and consequent keratinocyte accession; colonization of Propionibacterium acnes (P. acnes) and respective Staphylococcus albus and inflammation and immune response. The production of sebum by sebocytes is stimulated by androgens, such as testosterone, which in turn stimulate the production of sebocyt...