نتایج جستجو برای: 4b core protein

تعداد نتایج: 1427655  

Journal: :Journal of virology 2004
Nasser Khan Michael Guarnieri Sang Hoon Ahn Jisu Li Yonghong Zhou Genie Bang Kyun-Hwan Kim Jack R Wands Shuping Tong

Alteration in hepatitis B virus (HBV) secretion efficiency may have pathological consequences. Naturally occurring mutations that regulate virion secretion have not been defined. We recently identified HBV genomes displaying high (4B), substantially reduced (3.4), or negative (4C) virion secretion. In the present study, the underlying mutations were mapped. A T552C point mutation in the 4B geno...

Journal: :hepatitis monthly 0
danesh kadjbaf baqiyatallah research center for gastroenterology and liver diseases, baqiyatallah university of medical sciences, tehran, ir iran; school of medicine, tehran university of medical sciences (tums), tehran, ir iran maryam keshvari blood transfusion research center, high institute for research and education in transfusion medicine, tehran, ir iran seyed moayed alavian baqiyatallah research center for gastroenterology and liver diseases, baqiyatallah university of medical sciences, tehran, ir iran; middle east liver disease (meld) center, tehran, ir iran ali pouryasin armin pathobiology laboratory, tehran, ir iran; department of biology, arsanjan branch, islamic azad university, arsanjan, ir iran bita behnava baqiyatallah research center for gastroenterology and liver diseases, baqiyatallah university of medical sciences, tehran, ir iran; middle east liver disease (meld) center, tehran, ir iran shima salimi baqiyatallah research center for gastroenterology and liver diseases, baqiyatallah university of medical sciences, tehran, ir iran; middle east liver disease (meld) center, tehran, ir iran

conclusions there is an as yet unexplained association between hcv and host parameters with unknown mechanisms in patients with chronic hcv infection. the assessments of core aa 70 substitution and polymorphisms near the ifnl3 gene could offer promising steps to improve the management of patients with hcv. background molecular studies have demonstrated that the hepatitis c virus (hcv) genotype ...

Journal: :Molecular medicine reports 2015
Xiao-Hua Jiang Yu-Tao Xie Bo Jiang Meng-Ying Tang Tao Ma Hua Peng

The present study aimed to evaluate the silencing effect of artificial microRNAs (amiRNAs) against the hepatitis C virus (HCV) 1b (HCV1b) genotype core (C) and non-structural protein 4B (NS4B) genes. pDsRed-monomer-Core and pDsRed-monomer-NS4B plasmids, containing the target genes were constructed. A total of eight artificial micro RNA (amiRNA)-expressing plasmids, namely, pmiRE-C-mi1 to -mi4 a...

Journal: :iranian journal of biotechnology 2015
seyyedeh masumeh mirnurollahi azam bolhassani shiva irani noushin davoudi

background: hepatitis c virus (hcv) is a main public health problem causing chronic liver infection and subsequently liver cirrhosis and lethal hepatocellular carcinoma (hcc). vaccination based on hcv capsid proteins has attracted a special interest for prevention of viral infections. the core protein is a basic and evolutionary most conserved protein, which regulates the cellular processes rel...

Journal: Vaccine Research 2015
A Bolhassani , N Davoudi , Sh Irani, SM Mirnurollahi ,

Introduction: Hepatitis C virus (HCV) infection is a major public health problem which influences about 170 million people worldwide. Different types of vaccines have been designed using HCV structural proteins to control the viral infection. The core nucleocapsid protein is one of the most conserved proteins and a desirable target for HCV vaccines, especially the protein-based vaccines. In cur...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2015
Juan Antonio Rodríguez-Feo Marta Puerto Carolina Fernández-Mena Cristina Verdejo José Manuel Lara María Díaz-Sánchez Emilio Álvarez Javier Vaquero Ignacio Marín-Jiménez Rafael Bañares Luis Menchén

Inflammatory bowel disease (IBD) is characterized by an impaired intestinal barrier function. We aimed to investigate the role of reticulon-4B (RTN-4B/NOGO-B), a structural protein of the endoplasmic reticulum, in intestinal barrier function and IBD. We used immunohistochemistry, confocal microscopy, real-time PCR, and Western blotting to study tissue distribution and expression levels of RTN-4...

Background: Hepatitis C virus (HCV) is a main public health problem causing chronic liver infection and subsequently liver cirrhosis and lethal hepatocellular carcinoma (HCC). Vaccination based on HCV capsid proteins has attracted a special interest for prevention of viral infections. The core protein is a basic and evolutionary most conserved protein, which regulates the cellular processes rel...

Journal: :The Journal of biological chemistry 1993
S S Patel M M Hingorani

The oligomeric structure of bacteriophage T7 gene 4 helicase/primase proteins was investigated using protein cross-linking and high pressure gel-filtration chromatography. Studies were carried out with both 4A' and 4B proteins. 4A' is a M64L mutant of 4A which has similar helicase and primase activities as the wild-type mixture of 4A and 4B proteins (Patel, S. S., Rosenberg, A. H., Studier, F. ...

Journal: :Journal of physics 2021

Abstract Aiming at the fast opening and closing speed of GIS isolation/grounding switch, manual observation is more difficult, so it difficult to judge current switch status. This paper proposes an OpenCV-based image identification algorithm identify position movable contact during process isolating thereby judging state switch. system uses Raspberry Pi as main hardware core, server drives CMOS...

Journal: :The Journal of biological chemistry 1989
P T Tuazon W C Merrick J A Traugh

Four initiation factors (eIF-2, -3, -4B, and -4F), previously shown to be phosphorylated in vivo, are each phosphorylated to a significant extent in vitro (greater than 0.3 mol of phosphate/mol of factor) by at least three different protein kinases. An S6 kinase from liver, an active form of protease-activated kinase II which modifies the same sites on S6 as those phosphorylated in vivo in resp...

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