The hypoxia-inducible transcription factor (HIF-1alpha) plays a central role in tumor development. PX-478 is an experimental anti-cancer drug known to inhibit HIF-1alpha in experimental tumors. The purpose of this study was to identify MRS-visible metabolic biomarkers for PX-478 response prior to phase I/II clinical trials. Single-voxel in vivo localized (1)H spectra were obtained from HT-29 tu...

Two mesophilic streptomycetes (S. violaceoruber and S. spiroverticillatus) were selected to study their Poly R-478 decolorization ability and lignocellulose solubilizing activity. Both strains were able to degrade Poly R-478 dye and ferulic acid during growth on a minimal salts medium. The Poly R-478 decolorizing activities of both strains were induced by adding different carbon sources to the ...

PMCID: PMC3232567 Stenting of the aortic arch as an emergency palliation of aortic dissection after cardiac surgery in an infant M Emmel, N Sreeram, and K Brockmeier Contact information: Dr. N. Sreeram, Department Pediatric Cardiology, University Hospital of Cologne, Kerpenerstrasse 62, 50937 Cologne, Germany Phone: 0049 221 478 86301 0049 221 478 86301 Fax: 0049 221 478 86302 ; Email: N.Sreera...

CONTENTS PAGE Introduction 465 A definition and some general principles 468 Neuromuscular paradigms of neurotrophic competition 471 Innervation of smooth muscle 471 Innervation of skeletal muscle 472 Indirect evidence for spatial competition in skeletal muscle 473 Predictions regarding plasticity of smooth and skeletal muscle innervation 474 Competition versus co-existence of motor nerve termin...

The hypoxia-inducible factor-1 (HIF-1) transcription factor is an important regulator of tumor response to hypoxia that include increased angiogenesis, glycolytic metabolism, and resistance to apoptosis. HIF-1 activity is regulated by the availability of the HIF-1alpha subunit, the levels of which increase under hypoxic conditions. PX-478 (S-2-amino-3-[4'-N,N,-bis(2-chloroethyl)amino]phenyl pro...

Address for correspondence: Prof. Dr. med. Robert H.G. Schwinger, M.D., Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Joseph-Stelzmann-Str. 9, 50924 Cologne, Germany, telephone: 0049-221-478-3138, fax: 0049-221-478-3746, Email: [email protected] Articles in PresS. Am J Physiol Heart Circ Physiol (May 27, 2...

Growing tumors are hypoxic and respond to microenvironmental stress through increased expression of the hypoxia inducible factor-1alpha (HIF-1alpha) transcription factor, resulting in an adaptive switch to glycolytic metabolism, angiogenic signaling, survival, and metastasis. HIF-1alpha expression is associated with tumor resistance to cytotoxic therapy and inferior patient outcomes. Pancreatic...