The present work investigates, in situ, the in vitro bioactivity of partially crystallized 45S5 Bioglass (BG) as a function of immersion time in a simulated body fluid (SBF) using atomic force microscopy (AFM). The results obtained for the crystallized BG were compared to those of hydroxyapatite c- and a-faces. The calcium phosphate layer grows on the crystallized 45S5 B by multiple two-dimensi...

The aim of this study was to investigate the histological and histomorphometrical bone response to three Biosilicates with different crystal phases comparing them to Bioglass 45S5 implants used as control. Ceramic glass Biosilicate and Bioglass 45S5 implants were bilaterally inserted in rabbit femurs and harvested after 8 and 12 weeks. Histological examination did not revealed persistent inflam...

INTRODUCTION: Osteoporotic patients, smokers and diabetics are among those who represent higher risks with regard to bone formation. In these clinical situations where bone regeneration can be especially difficult there is a need for an active agent or material which can stimulate osteoblasts in addition to providing a scaffold for growth. Extensive research has been performed on silicon and ca...

-The bioactive glass 45S5 (Hench glass), having composition 45 SiO2 24.5 Na2O 24.5 CaO -6 P2O5 (wt %) were prepared with substituted Li2O, K2O, ZnO, MgO, and B2O3 by conventional melting process in an electric globar furnace at 1400±10 OC. The Controlled crystallization were carried out to convert the bioglasses to their corresponding bioglass ceramics. Nucleation and crystallization regimes we...

  Objective: Bioactive glass 45S5 is a surface reactive glass-ceramic biomaterial, developed in 1969. BAG 45S5 with particle size of 20-60 nm has the ability of bone regeneration, broad spectrum antibacterial effect, repairs and replaces diseased or damaged bone. The aim of this study was to evaluate the antibacterial activity and determine MIC and MBC values of nano-BAG45S5 on Streptococcus mu...

Bioactive glasses (BAGs) are highly interesting materials for bone regeneration applications in orthopedic and dental defects. It is quite well known that ionic release from BAGs influences cell behavior and function. Mindful of the clinical scenario, we hypothesized that local cell populations might additionally physically interact with the implanted BAG particles and respond differently than ...

Osteoporosis is a disease characterized by structural deterioration of bone tissue, leading to skeletal fragility with increased fracture risk. Calcium phosphates (CaPs) are widely used in bone tissue engineering strategies as they have similarities to bone apatite except for the absence of trace elements (TEs) in the CaPs. Bioactive glasses (BGs) have also been used successfully in clinic for ...

The objective of the study was to compare the acid neutralizing ability and shear bond strength (SBS) of three different types of orthodontic adhesives containing bioactive glasses (BAGs). 45S5, 45S5F and S53P4 BAGs were prepared using the melting technique and ground to fine particles. Orthodontic adhesives containing three types of BAGs were prepared as follows: 52.5% 45S5 BAG + 17.5% glass (...

The use of porous titanium samples fabricated by space-holder powder metallurgy with bioactive coatings has already been reported to prevent resorption the bone surrounding implant and improve osseointegration, respectively. However, presence pores as well poor adherence brittle behavior inherent glassy affect service implants from these samples. Therefore, they need be optimized. In this work,...

Reconstruction and augmentation of the alveolar bone defects pose a challenge for dental surgeons due to its complex structure. The primary objective tissue engineering is regenerate or replace damaged tissues organs including with grafts, cells, biological molecules. 45S5-bioglass (45S5-BG), superior osteoconductive osteoinductive abilities, has been at forefront engineering, regeneration, per...