Tacrolimus requires close therapeutic drug monitoring because of its narrow therapeutic index and marked interindividual pharmacokinetic variation. In this study, we investigated the associations of polymorphisms in the gene encoding 11b-hydroxysteroid dehydrogenase type 1 (HSD11B1) with tacrolimus concentrations in Chinese renal transplant recipients during the early posttransplantation stage....

Tacrolimus requires close therapeutic drug monitoring because of its narrow therapeutic index and marked interindividual pharmacokinetic variation. In this study, we investigated the associations of polymorphisms in the gene encoding 11b-hydroxysteroid dehydrogenase type 1 (HSD11B1) with tacrolimus concentrations in Chinese renal transplant recipients during the early posttransplantation stage....

Tacrolimus requires close therapeutic drug monitoring because of its narrow therapeutic index and marked interindividual pharmacokinetic variation. In this study, we investigated the associations of polymorphisms in the gene encoding 11b-hydroxysteroid dehydrogenase type 1 (HSD11B1) with tacrolimus concentrations in Chinese renal transplant recipients during the early posttransplantation stage....

Tacrolimus requires close therapeutic drug monitoring because of its narrow therapeutic index and marked interindividual pharmacokinetic variation. In this study, we investigated the associations of polymorphisms in the gene encoding 11b-hydroxysteroid dehydrogenase type 1 (HSD11B1) with tacrolimus concentrations in Chinese renal transplant recipients during the early posttransplantation stage....

Bilindiği üzere, Secâvendî vakfı; lâzım ( م ), mutlak ط caiz ج mücevvez li-vechin ز murahhas zarureten ص ) ve gayr-ı câiz لا olmak üzere altı kategoriye ayırmış bu kategorileri parantez arasında belirttiğimiz harflerden belirlediği sembollerle göstermiştir. Türkiye’deki mushaflarda Secâvendî’nin sistemi tercih edilmiş olmasına rağmen, onun sisteminde bulunmayan kimi rumuzlar da kullanılmıştır. ...

In "Mathematical Games" in the December 1966 issue of Scientific American, Martin Gardner made the following statement regarding Pascals triangle: "Almost anyone can study the triangle and discover more properties, but it is unlikely that they will be new, for what is said here only scratches the surface of a vast literature." But, of course, many new results have been discovered since 1966 and...