Semi-synthetic triterpenoids are antioxidant inflammation modulator (AIM) compounds that inhibit tumor cell growth and metastasis. Compounds in the AIM class bind to Keap1 and attenuate Nrf2 degradation. In the nucleus, Nrf2 increases antioxidant gene expression and reduces pro-inflammatory gene expression. By increasing Nrf2 activity, AIMs reduce reactive oxygen species and inflammation in the...

In this paper we estimated the temperatures and brightnesses of the Monoceros radio loop at 1420, 820 and 408 MHz. Linear spectrum is estimated for mean temperatures versus frequency between 1420, 820 and 408 MHz. The spectral index of Monoceros loop is also obtained. The brightness temperatures and surface brightnesses of the loop are computed using data taken from radio-continuum surveys at t...

*Correspondence: [email protected] Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA Full list of author information is available at the end of the article doi:10.1186/ar3177 Cite this article as: Lotz MK, Kraus VB: Correction: Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options....

We present a new 408MHz survey (B3.2) carried out with the “Croce del Nord” radiotelescope in Bologna. The survey coordinates limits are −2◦00′ to +2◦15′ in Dec. and 21h to 24h, 00h to 17h in R.A., equivalent to 0.388 sr. The B3.2 is complete to 0.15 Jy but many sources down to 0.1 Jy are included. Our aim was to select a new and complete sample of Ultra Steep Spectrum (USS) radio sources, as t...

We often think of graphs geometrically, i.e. we see vertices as points on a plane or in space, with edges as lines connecting them. When speci ed algebraically (e.g. by its adjacency matrix), the geometrical imagery is absent. Can we somehow create it from the algebraic description? The geometric representation might be useful in itself, say because we want to draw the graph on paper. But once ...

In this paper, we examine the economics of Rule 408 of the Federal Rules of Evidence, whereby the negotiation processes at the pretrial stage are made inadmissible to prove the amount of liability. It is asserted that under Rule 408 a settlement offer is less inclined to be rejected since the judge is expected to make a lower award given the signal he observes. Also, we derive a sufficient cond...