GR99060 and GR99062 are representatives of a series of 1,2,4-triazino[5,6-b]indole compounds. This series possessed broad-spectrum antifungal activity in vitro. The MIC ranges of the two compounds were as follows: 0.25 to 4 micrograms/ml for Candida albicans, 0.25 to 16 micrograms/ml for Candida sp., 1 to 8 micrograms/ml for Aspergillus spp., and 0.25 to 16 micrograms/ml for Cryptococcus neofor...

It has come to the authors’ attention that an inadvertent error was made during preparation of Figure 2 f and 3 d in this Communication. In label for Y axis should read Rt(Ω). original line (grey line) fitting (red dotted C1s at −20 °C SEI were copied by mistake plotting. The corrected versions Figures are shown below. changes do not alter interpretation data or conclusions published work. auth...

In the present study, we observed expression and changes of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) in the gerbil hippocampal CA1 region, but not in the CA2/3 region, after 5 min of transient forebrain ischemia. In blood, corticosterone levels were increased biphasically at 30 min and 12 h after ischemia/reperfusion, and thereafter its levels were decreased. In the sham...

The purpose of this study was to investigate the effects of temperature, velocity and load on the gliding resistance (GR) of flexor digitorum profundus (FDP) tendons in a human cadaver model. A total of 40 FDP tendons from the index through small digits of ten human cadavers were tested to assess the effect of temperature (4, 23 or 36 °C), velocity (2, 4, 6, 8, 10 or 12 mm/s) and load (250, 500...

Many cellular responses to corticosteroids involve the transcriptional modulation of target genes by the glucocorticoid receptor (GR). A rapid, non-nuclear effect of GR was found to mediate neuroprotection. High-dose corticosteroids (20 mg/kg intraperitoneally), given within 2 hours of transient cerebral ischemia, acutely increased endothelial nitric oxide synthase (eNOS) activity, augmented re...

Bacillary dysentery and acute gastroenteritis caused by infection of Shigella species are major public health burden in India and its neighboring countries. Emergence of antimicrobial resistance threatens to render current treatments ineffective. The current study was attempted to investigate the effect of biofield treatment on Shigella boydii (S. boydii) with respect of antimicrobial susceptib...

Surface modification is a promising approach to modulate the electrocatalyst properties for their further use in energy storage and conversion. In this work, electrochemical-based was proposed generate metallic particles-supported graphite rod (GR). The based on cathodic activation of GR presence alkali metal salts dry organic solvent. activated possess high reducing power that successfully emp...

The glucocorticoid receptor (GR) is a central player in the neuroendocrine stress response; it mediates feedback regulation of the hypothalamus-pituitary-adrenal (HPA) axis and physiological actions of glucocorticoids in the periphery. Despite intensive investigations of GR in the context of receptor-ligand interaction, only recently the first naturally occurring gain-of-function substitution, ...

The hypothalamic-pituitary-adrenal (HPA) axis is susceptible to programming during fetal life. Such programming occurs, at least partially, at the level of the hippocampus. The hippocampus plays a central role in regulation of the HPA axis and release of endogenous glucocorticoids, via mediation of glucocorticoid negative feedback. Fetal exposure to synthetic glucocorticoids can permanently alt...

Bu çalışmada, ağırlıkça %10, %20 ve %40 Bor Karbür (B4C) içerikli Al matris partiküllerin kompakt malzemelerin üretimi karakterizasyonu gerçekleştirilmiştir. B4C takviyeli elektriksel iletkenlik değerleri en düşük 6,97 %IACS yüksek 20,73 olarak belirlenmiştir. Deneysel çalışmalar sonucunda, mikro yapıda artan takviyesinin yapının yoğunluğunu azaltma sertliğini arttırma noktasında olumlu etkisi ...