نتایج جستجو برای: 4 tetrazole 5 thiol
تعداد نتایج: 2073587 فیلتر نتایج به سال:
Eleven oxytocin analogues substituted in position 4, 5 or 9 by tetrazole analogues of amino acids were prepared using solid-phase peptide synthesis method and tested for rat uterotonic in vitro and pressor activities, as well as for their affinity to human oxytocin receptor. The tetrazolic group has been used as a bioisosteric substitution of carboxylic, ester or amide groups in structure-activ...
A new activator for the coupling of phosphoramidites to the 5'-hydroxyl group during oligonucleotide synthesis is introduced. The observed time to complete coupling is twice as fast with 4, 5-dicyanoimidazole (DCI) as the activator, compared with 1 H -tetrazole. The effectiveness of DCI is thought to be based on its nucleophilicity. DCI is soluble in acetonitrile up to 1.1 M at room temperature...
Development of a new improved and efficient process suitable for the large-scale production of Irbesartan has been described. The key steps are tetrazole formation from secondary amide for the preparation of the key intermediate 1-Benzyl-5-(4'-bromomethyl-biphenyl-2-yl)-1H-tetrazole (9), N-alkylation and debenzylation.
Recently there has been increased interest in high nitrogen content “green” energetic materials which are designed to produce relatively non-toxic decomposition products as part of a push to decrease the environmental impact of energetic materials through all phases of their existence. With the use of a T-Jump/Time-of-Flight Mass Spectrometer (T-Jump/TOFMS) capable of high heating rates (up to ...
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