N-N-linked dimeric indole alkaloids represent an unexplored class of natural products for which chemical synthesis has no practical solution. To meet this challenge, an electrochemical oxidative dimerization method was developed, which was applied as the pivotal step of the first total synthesis of dixiamycin B. This method is also general for N-N dimerization of substituted carbazoles and β-ca...

Thermally induced [4+2] cycloaddition reactions of 5-ethanesulfonyl2-methylpyridazin-3(2H)-one (2) with pyrano[3,4-b]indol-3(9H)-ones (1, 4) affords isomeric pyridazino[4,5-b]carbazolones (3a,b, 5a,b), the product ratio depending on the substitution pattern of the diene. Two carbazolocarbazoles (6, 7) were obtained as side products. The antineoplastic activity of ellipticine (5,11-dimethyl-6H-p...

Functionalising 2,5-di(N,N'-carbazolyl)terephthalonitrile or 2,3,5,6-tetra(N,N'-carbazolyl)terephthalonitrile on the carbazole moiety with alkoxy chains, gives a family of materials that show TADF response; two them are also liquid crystalline.

Aromatic dicationic molecules possess impressive activity against a broad spectrum of microbial pathogens, including Pneumocystis carinii, Cryptosporidium parvum, and Candida albicans. In this work, 58 aromatic cations were examined for inhibitory activity against axenic amastigote-like Leishmania donovani parasites. In general, the most potent of the compounds were substituted diphenyl furan a...

Research into environmentally friendly strategies for hydrogen transfer reduction is increasing, along with the need more elaborate heterocyclic platforms. Within this context, we develop a new approach substituted dihydrobenzo[c]carbazoles and indoles. These compounds were synthesized through an iron-catalyzed of nitroarenes, followed by intramolecular cyclization. This transformation involves...

5,12-Dihydroindolo[3,2-a]carbazole is a polycyclic structure combining in its scaffold two carbazole moieties sharing fused aromatic ring. Since the pioneering works reported 2019 on this concerning substitution of carbazoles by similar functional groups, no recent investigation has been devoted to asymmetrize carbazoles. In work, series 13 compounds based 5,12-dihydroindolo[3,2-a]carbazole pre...

A facile synthesis of hitherto unreported 3-(2-benzofuroyl)carbazoles 3a-k, 3,6-bis(2-benzofuroyl)carbazoles 5a-k, and naphtho[2,1-b]furoylcarbazoles 3l and 5l is described. The synthesis mainly relies on the ultrasound-assisted Rap-Stoermer reaction of 3-chloroacetyl- (1) or 3,6-dichloroacetyl-9-ethyl-9H-carbazole (4) with various salicylaldehydes 2a-k as well as 2-hydroxy-1-naphthaldehyde (2l...

ion 260 Preparation of Dibenzofurafls and Related Hetero-analogues 268 Preparation of Dibenzofurans 268 Preparation of Dibenzothiophenes 281 Attempted Preparation of Carbazoles and N-Methylcarbazoles 289 4.. Preparation of Fluorene and Fluorenone 298