WR182393, a guanidinoimidazolidinedione derivatives with potent causal prophylactic antimalarial activity by intramuscular injection, was previously prepared by treatment of chloroproguanil and diethyl oxalate, yielding a mixture of two closely related isomers. Poor solubility of the mixture made the separation and purification impossible. To overcome the separation problem, new and facile unam...

Epilepsy is a major neurological disorder in the world and most epileptics are currently controlled by a variety of drugs. 5, 5-diphenylimidazolidine-2,4-dione (Phenytoin, I) is a widely used antiepileptic drug. It has been synthesized previously by different methods in some solvents. In this work, I was synthesized from the condensation of benzil and urea in ethanol and water by application of...

From ancient years, the traditional medicinal plants were used for the treatment of various diseases. Nowadays several researches have been focused on medicinal plant aiming to search for efficient alternatives to control pathogenic agents. The Natural products (NP) rise as promising tools in the production of novel drugs. Since many compounds were found in plants with high secondary metabolite...

Many rapidly firing neurons, including those in the medial nucleus of the trapezoid body (MNTB) in the auditory brain stem, express "high threshold" voltage-gated Kv3.1 potassium channels that activate only at positive potentials and are required for stimuli to generate rapid trains of actions potentials. We now describe the actions of two imidazolidinedione derivatives, AUT1 and AUT2, which mo...

Because 1,2,4-triazoles exhibit a wide spectrum of pharmacological effects, which express a great metabolic polysemy, their structure interpretation is possible in terms of various metabolic pathways at whose level acts this triazoles. In this context, present paper propose an interpretation of the anticancer properties of light intrusion triazole compounds in the basic metabolism of nitrate ta...