BACKGROUND The loop diuretic frusemide has been shown to inhibit the bronchoconstrictor response to exercise, inhaled allergen, distilled water, adenosine, and sodium metabisulphite. Toluene diisocyanate contracts smooth muscle by activating capsaicin sensitive nerves and causes asthma that shares many features with allergen induced asthma. METHODS The study was designed to assess the effect ...

The inhalation of isocyanates, such as toluene diisocyanate (TDI), diphenylmethane diisocyanate (MDI), and hexamethylene diisocyanate (HDI) can induce hypersensitivity pneumonitis (HP) as well as bronchial asthma in humans, but the precise pathological features and their pathogenetic mechanisms have not been elucidated. To provide insight into the pathological features of isocyanate-induced hyp...

in this study, rice husk and sodium silicate solution were used to produce particleboards. sodium silicate was used as bonding aid by 25, 20, 15, 10, 5 and zero percent (based on rice husk dry weight). to modify the mechanism of bondability, one percent of 4,4’-diphenylmethane diisocyanate (mdi) was added for every five percent less sodium silicate solution. the effect of diisocyanate on bondab...

OBJECTIVES Diisocyanates (DIC) are highly reactive, low-molecular-weight chemicals which are the leading cause of occupational asthma (OA). The aim of the study was to analyze certain aspects of the pathogenesis of allergic inflammation in the airways induced by toluene diisocyanate (TDI) in an experimental model in mice. MATERIALS AND METHODS The experiment was carried out on 50 female BALB/...

This work reports a new method to covalently attach calix[4]arene derivatives onto MCM-41, using a diisocyanate as a linker. The modified mesoporous silicates were characterized by fourier transform infrared spectroscopy (FTIR), thermal analysis (TGA) and elemental analysis. The FTIR spectra and TGA analysis verified that the calix[4]arene derivates are covalently attached to the mesoporous sil...

Inhalation challenges to isocyanates are conducted in specialized centers to confirm occupational asthma. The pattern of asthmatic reactions due to consecutively increasing daily doses of isocyanates is unknown. We conducted a study involving 24 subjects who had undergone specific inhalation challenges to isocyanates (toluene diisocyanate [TDI], n = 8; hexamethylene diisocyanate [HDI], n = 10; ...

1.1 Chemical and physical data 1.1.1 Nomenclature Chem. Abstr. Serv. Reg. No.: (a) 101-68-8 (monomer) and (b) 26447-40-5 Chem. Abstr. Name: 1,1′-Methylenebis(4-isocyanatobenzene) IUPAC Systematic Names: For 101-68-8: isocyanic acid, methylenedi-paraphenylene ester Synonyms: Bis(1,4-isocyanatophenyl)methane; diphenylmethane diisocyanate; MDI; methylenedi-para-phenylene isocyanate and for 26447-4...

Anionic polyurethane dispersants APUDs were used as dispersing agents in formulation of waterborne paints. The APUDs were synthesized by three steps. In the first step, macromonomer diisocyanate having carboxylic acid was prepared by isophorone diisocyanate IPDI, dimethylol propionic acid DMPA in presence of acetone as solvent and dibutyltin dilaurate DBTDL as catalyst. Then, carboxylic polyure...