نتایج جستجو برای: 4 dihydropyrimidinone
تعداد نتایج: 1303651 فیلتر نتایج به سال:
Abstract The enaminone, (2 E )-3-(dimethylamino)-1-(3,4,5-trimethoxyphenyl) prop-2-en-1-one was prepared by refluxing 3,4,5-trimethoxy acetophenone with dimethylformamide dimethylacetal (DMF–DMA) without solvent for 12 h. dihydropyrimidinone derivatives (1–9) were reacting substituted benzaldehydes and urea in glacial acetic acid. compounds synthesized significant yield using one step multicomp...
a condensation of various isatins with indole derivatives has been carried out in the presence of 1,3-dibromo-5,5-dimethylhydantoin (dbdmh) as catalyst at 50 °c in ethanol in order to form 3,3-bis(indolyl) oxindoles. the products were obtained within 20-90 min by 70-96% yields. the efficacy of the procedure has been confirmed by catalyzing the condensation reaction of pyrrole which was used as ...
Abstract In response to the malaria parasite’s resistance towards quinoline-based antimalarial drugs, we have employed quinoline-containing compounds in combination with dihydropyrimidinone (DHPM) analogues as reversal agents (RAs) and investigated their activities based on DHPM’s abilities. The present study click chemistry link DHPM quinoline which offered several synthetic advantages over pr...
Background and Objective: A Simple, Green and efficient procedure for the synthesis of 4-aryl-3, 4-dihydropyrimidine-2(1H)-ones/thione (Biginelli reaction) from 1, 3-dicarbonyl compound, substituted aldehydes and urea/thiourea in the presence of Sodium Dodecyl Sulphate (SDS), a novel catalyst has been introduced in this study. Materials and Methods: The structures of these compounds have been c...
Human neutrophil elastase (HNE) is a key protease for matrix degradation. High HNE activity is observed in inflammatory diseases. Accordingly, HNE is a potential target for the treatment of pulmonary diseases such as chronic obstructive pulmonary disease (COPD), acute lung injury (ALI), acute respiratory distress syndrome (ARDS), bronchiectasis (BE), and pulmonary hypertension (PH). HNE inhibit...
Therapies to prevent onset and progression of pulmonary arterial pressure are not very effective yet. This study was designed to investigate the effects of a novel dihydropyrimidinone, ethyl 4-(4′-heptanoyloxyphenyl)-6methyl-3,4-dihydropyrimidin-2-one-5-carboxylate (H-DHPM) on pathogenesis of monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH). For the same purpose, rats were inje...
the aim of this research is to study ni2+ supported on hydroxyapatite-core-shell magnetic γ-fe2o3 nanoparticles (γ-fe2o3@hap-ni2+) as a green and recyclable catalyst for the biginelli reaction under solvent-free conditions. one-pot multi-component condensation of 1,3-dicarbonyl compounds, urea and aldehydes at 80 oc affords the corresponding compounds in high yields and in short reaction times ...
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